Mammalian Numb protein antagonizes Notch by controlling postendocytic trafficking of the Notch ligand Delta-like 4.

Shao, Ximing; Ding, Zhihao; Zhao, Ming; Liu, Ke; Sun, Haiyan; Chen, Juntao; Liu, Xianming; Zhang, Yuzhen; Hong, Yang; Li, Huashun; Li, Hongchang

Shao, Ximing; Ding, Zhihao; Zhao, Ming; Liu, Ke; Sun, Haiyan; Chen, Juntao; Liu, Xianming; Zhang, Yuzhen; Hong, Yang; Li, Huashun; Li, Hongchang.

Afiliação

Shao X; From the Shenzhen Key Laboratory for Molecular Biology of Neural Development, Guangdong Key Laboratory of Nanomedicine, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong 518055, China.
Ding Z; From the Shenzhen Key Laboratory for Molecular Biology of Neural Development, Guangdong Key Laboratory of Nanomedicine, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong 518055, China.
Zhao M; the Department of Oncology, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China.
Liu K; From the Shenzhen Key Laboratory for Molecular Biology of Neural Development, Guangdong Key Laboratory of Nanomedicine, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong 518055, China.
Sun H; From the Shenzhen Key Laboratory for Molecular Biology of Neural Development, Guangdong Key Laboratory of Nanomedicine, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong 518055, China.
Chen J; From the Shenzhen Key Laboratory for Molecular Biology of Neural Development, Guangdong Key Laboratory of Nanomedicine, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong 518055, China.
Liu X; From the Shenzhen Key Laboratory for Molecular Biology of Neural Development, Guangdong Key Laboratory of Nanomedicine, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong 518055, China.
Zhang Y; the Research Center for Translational Medicine, Key Laboratory of Arrhythmias of the Ministry of Education of China, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China.
Hong Y; the Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, and.
Li H; the ATCG Corp., BioBay, Suzhou Industrial Park, Suzhou, Jiangsu 215123, China huashunli@tongji.edu.cn.
Li H; From the Shenzhen Key Laboratory for Molecular Biology of Neural Development, Guangdong Key Laboratory of Nanomedicine, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong 518055, China, hc.li@siat.ac.cn.

J Biol Chem ; 292(50): 20628-20643, 2017 12 15.

Article em En | MEDLINE | ID: mdl-29042443

Assuntos

Proteínas Adaptadoras de Transporte Vesicular/metabolismo; Endocitose; Endotélio Vascular/metabolismo; Peptídeos e Proteínas de Sinalização Intercelular/metabolismo; Proteínas de Membrana/metabolismo; Proteínas do Tecido Nervoso/metabolismo; Receptor Notch1/antagonistas & inibidores; Transdução de Sinais; Complexo 1 de Proteínas Adaptadoras/metabolismo; Proteínas Adaptadoras de Transdução de Sinal; Proteínas Adaptadoras de Transporte Vesicular/genética; Proteínas de Ligação ao Cálcio; Comunicação Celular; Linhagem Celular Transformada; Técnicas de Cocultura; Endotélio Vascular/citologia; Células Endoteliais da Veia Umbilical Humana/citologia; Células Endoteliais da Veia Umbilical Humana/metabolismo; Humanos; Peptídeos e Proteínas de Sinalização Intercelular/genética; Peptídeos e Proteínas de Sinalização Intracelular; Ligantes; Proteínas de Membrana/antagonistas & inibidores; Proteínas de Membrana/genética; Proteínas do Tecido Nervoso/agonistas; Proteínas do Tecido Nervoso/antagonistas & inibidores; Proteínas do Tecido Nervoso/genética; Estabilidade Proteica; Transporte Proteico; Interferência de RNA; Receptor Notch1/agonistas; Receptor Notch1/genética; Receptor Notch1/metabolismo; Proteínas Recombinantes de Fusão/metabolismo; Proteínas Recombinantes/metabolismo

Palavras-chave

Delta-like 4; Notch pathway; Numb; cell signaling; endocytosis; intracellular trafficking; protein degradation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Endotélio Vascular / Transdução de Sinais / Peptídeos e Proteínas de Sinalização Intercelular / Proteínas Adaptadoras de Transporte Vesicular / Endocitose / Receptor Notch1 / Proteínas de Membrana / Proteínas do Tecido Nervoso Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2017 Tipo de documento: Article País de afiliação: China

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