Prolactin release induced by opiate agonists, effect of glucocorticoid pretreatment in intact and adrenalectomized rats.
Neuroendocrinology
; 48(2): 174-9, 1988 Aug.
Article
em En
| MEDLINE
| ID: mdl-2906115
ABSTRACT
Cortisol administered at a dose of 25 mg/kg 24 h before measurements decreased the prolactin secretion induced by intraventricularly given opioids (dynorphin, beta-endorphin, Met-enkephalin or D-Met-Pro-enkephalinamide). The effect of cortisol was depressed by actinomycin D pretreatment. The cortisol-induced inhibition of the action of morphine was facilitated in adrenalectomized animals; measuring the effects of increasing doses of cortisol a maximal inhibition was obtained at a dose of 5 mg/kg. The opioid-induced corticosterone secretion was not affected 24 h after a single administration of cortisol. The present results show that the cortisol-induced inhibition of opioid-induced prolactin secretion is dependent on protein synthesis and independent of changes in drug metabolism, and of the type of opiate receptor preferentially affected by the opiate agonists employed.
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Base de dados:
MEDLINE
Assunto principal:
Prolactina
/
Hidrocortisona
/
Endorfinas
/
Ventrículos Cerebrais
/
Adrenalectomia
Limite:
Animals
Idioma:
En
Revista:
Neuroendocrinology
Ano de publicação:
1988
Tipo de documento:
Article