Lipid profile and bone mineral density in heavy alcoholics.
Clin Nutr
; 37(6 Pt A): 2137-2143, 2018 12.
Article
em En
| MEDLINE
| ID: mdl-29089152
ABSTRACT
BACKGROUND & AIMS:
Some studies have illustrated the association between serum lipid profile and bone mineral density (BMD) or fractures. None of these studies was performed among alcoholics, despite the fact that alcoholism may affect both bone mass and lipid metabolism. We here analyse the relationship of serum lipid profile with bone mass among a population of 280 heavy alcoholics (29 women).METHODS:
patients underwent a densitometric assessment of BMD and determination of a serum lipid panel. Castelli index (Total cholesterol/HDL cholesterol) and the LDL/HDL cholesterol index were calculated.RESULTS:
There was a direct correlation between both total cholesterol and LDL-cholesterol and femoral neck (râ¯=â¯0.17 and râ¯=â¯0.20, respectively) and lumbar spine (râ¯=â¯0.16 and râ¯=â¯0.20) T score, total BMD (râ¯=â¯0.14 and râ¯=â¯0.18) or pelvis BMD (râ¯=â¯0.16 and râ¯=â¯0.23; pâ¯<â¯0.025 in all cases). HDL-cholesterol showed no relationship with BMD. Serum triglycerides were also directly related to T score at the lumbar spine (ρâ¯=â¯0.13; pâ¯=â¯0.032) and pelvis BMD (ρâ¯=â¯0.13; pâ¯=â¯0.037). Pelvis BMD was significantly related to Castelli index (ρâ¯=â¯0.15) and LDL/HDL index (ρâ¯=â¯0.18; pâ¯<â¯0.015 in both cases). Multivariate analysis showed that the association between the serum lipid panel and BMD was independent of liver function and body mass index.CONCLUSIONS:
Therefore, BMD was directly related to total cholesterol and LDL cholesterol in heavy alcoholism. This counter intuitive observation adds to others derived from several similar studies conducted in different population groups but not in alcoholics as of yet. The mechanisms that explain the association between serum lipids and bone metabolism need further investigation.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Densidade Óssea
/
Alcoolismo
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Lipídeos
Tipo de estudo:
Etiology_studies
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Incidence_studies
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Observational_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Clin Nutr
Ano de publicação:
2018
Tipo de documento:
Article