Progressive multifocal leukoencephalopathy in patients receiving rituximab and cyclophosphamide after haplo-identical T-cell replete transplantation and review of the literature.
Curr Res Transl Med
; 65(4): 127-132, 2017 11.
Article
em En
| MEDLINE
| ID: mdl-29132903
ABSTRACT
John Cunningham virus (JCV) reactivation, occurring mainly in immunocompromised patients, leads to progressive multifocal leukoencephalopathy, an uncommon but lethal disease. JCV reactivation after T-cell replete haploidentical stem cell transplantation, in the pre-cyclophosphamide era, is poorly represented in the literature. We therefore describe two cases of acute myeloid leukemia who developed JCV reactivation after receiving cyclophosphamide and rituximab post haploidentical stem cell transplantation, and review the literature, aiming to a better understanding of the disease course and its risk factors.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Leucemia Mieloide Aguda
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Leucoencefalopatia Multifocal Progressiva
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Transplante de Células-Tronco Hematopoéticas
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Condicionamento Pré-Transplante
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Ciclofosfamida
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Rituximab
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Transplante Haploidêntico
Tipo de estudo:
Risk_factors_studies
Limite:
Female
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Humans
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Middle aged
Idioma:
En
Revista:
Curr Res Transl Med
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Líbano