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Postlicensure safety surveillance of congenital anomaly and miscarriage among pregnancies exposed to quadrivalent human papillomavirus vaccine.
Sy, Lina S; Meyer, Kristin I; Klein, Nicola P; Chao, Chun; Velicer, Christine; Cheetham, T Craig; Ackerson, Bradley K; Slezak, Jeff M; Takhar, Harpreet S; Hansen, John; Deosaransingh, Kamala; Liaw, Kai-Li; Jacobsen, Steven J.
Afiliação
  • Sy LS; a Department of Research and Evaluation , Kaiser Permanente Southern California , Pasadena , CA , USA.
  • Meyer KI; a Department of Research and Evaluation , Kaiser Permanente Southern California , Pasadena , CA , USA.
  • Klein NP; b Kaiser Permanente Vaccine Study Center, Kaiser Permanente Northern California , Oakland , CA , USA.
  • Chao C; a Department of Research and Evaluation , Kaiser Permanente Southern California , Pasadena , CA , USA.
  • Velicer C; c Department of Epidemiology , Merck Research Laboratories , Upper Gwynedd , PA , USA.
  • Cheetham TC; a Department of Research and Evaluation , Kaiser Permanente Southern California , Pasadena , CA , USA.
  • Ackerson BK; d Department of Pediatrics and Pediatric Infectious Diseases , Southern California Permanente Medical Group , Harbor City , CA , USA.
  • Slezak JM; a Department of Research and Evaluation , Kaiser Permanente Southern California , Pasadena , CA , USA.
  • Takhar HS; a Department of Research and Evaluation , Kaiser Permanente Southern California , Pasadena , CA , USA.
  • Hansen J; b Kaiser Permanente Vaccine Study Center, Kaiser Permanente Northern California , Oakland , CA , USA.
  • Deosaransingh K; b Kaiser Permanente Vaccine Study Center, Kaiser Permanente Northern California , Oakland , CA , USA.
  • Liaw KL; c Department of Epidemiology , Merck Research Laboratories , Upper Gwynedd , PA , USA.
  • Jacobsen SJ; a Department of Research and Evaluation , Kaiser Permanente Southern California , Pasadena , CA , USA.
Hum Vaccin Immunother ; 14(2): 412-419, 2018 02 01.
Article em En | MEDLINE | ID: mdl-29140750
ABSTRACT
Limited safety data are available on inadvertent exposure to quadrivalent human papillomavirus vaccine (4vHPV) during pregnancy. We conducted a descriptive observational postlicensure safety surveillance study in Kaiser Permanente Southern California and Northern California to assess congenital anomaly and miscarriage among pregnancies exposed to 4vHPV. Using electronic medical records, we identified women who received a dose of 4vHPV between August 2006 and March 2008 within 30 days preconception or any time during a possible pregnancy. A broad algorithm was developed using diagnostic and procedure codes and laboratory tests to identify pregnancy, congenital anomalies, and miscarriages. Medical records of all potential congenital anomaly cases and a random sample of 100 potential miscarriage cases were reviewed to confirm pregnancy exposure and diagnosis. Results were reviewed by an independent Safety Review Committee (SRC). Among the population of 189,629 females who received at least one dose of 4vHPV during the study period, 2,678 females were identified as possibly having a 4vHPV-exposed pregnancy. Among 170 potential congenital anomalies identified, 44 (26%) were found to be both 4vHPV-exposed and confirmed congenital anomaly cases. Among the 633 potential miscarriages identified, the records of a random sample of 100 cases were reviewed, and 9 cases (9%) were confirmed as 4vHPV-exposed miscarriages. The SRC noted no safety signal for congenital anomaly or miscarriage associated with 4vHPV exposure during pregnancy. The rate of major congenital anomaly (3.6%) was in the range of background estimates from the literature. There was no apparent pattern of timing of 4vHPV exposure among 4vHPV-exposed miscarriages.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vigilância de Produtos Comercializados / Anormalidades Induzidas por Medicamentos / Aborto Espontâneo / Infecções por Papillomavirus / Vacinas contra Papillomavirus Tipo de estudo: Screening_studies Limite: Female / Humans / Newborn / Pregnancy Idioma: En Revista: Hum Vaccin Immunother Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vigilância de Produtos Comercializados / Anormalidades Induzidas por Medicamentos / Aborto Espontâneo / Infecções por Papillomavirus / Vacinas contra Papillomavirus Tipo de estudo: Screening_studies Limite: Female / Humans / Newborn / Pregnancy Idioma: En Revista: Hum Vaccin Immunother Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos