Metastatic Endocervical Adenocarcinoma in a Mature Cystic Teratoma: A Case of a Tumor-to-Tumor Metastasis.
Int J Gynecol Pathol
; 37(6): 559-563, 2018 Nov.
Article
em En
| MEDLINE
| ID: mdl-29140879
ABSTRACT
Tumor-to-tumor metastasis is a rare phenomenon defined as a metastasis in a histologically distinct tumor. We report an unusual case of a 51-yr-old woman who presented with a cervical, bleeding lesion diagnosed as a poorly differentiated adenocarcinoma, HPV18+. Imaging studies revealed an unresectable cervical carcinoma with an associated left ovarian multicystic teratoma. A suspicious solid nodule within the teratoma was also reported. Bilateral salpingo-oophorectomy was performed before the cervical tumor was treated. Pathologic findings showed a multicystic tumor measuring 110×40×30 mm with an area of adenocarcinoma, morphologically similar to the cervical neoplasm. The immunoprofile obtained in the malignant ovarian component (p16+, carcinogenic embryonic antigen+, vimentin-, estrogen receptor-) was similar to the one in the cervix. Moreover, both lesions harbored HPV18. These findings confirmed the presence of a metastatic cervical adenocarcinoma in a mature cystic teratoma. In the differential diagnosis, both somatic malignant transformation of the mature cystic teratomas and the presence of a "collision tumor" were considered and are discussed in this case report.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Teratoma
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Adenocarcinoma
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Neoplasias do Colo do Útero
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Colo do Útero
Limite:
Female
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Humans
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Middle aged
Idioma:
En
Revista:
Int J Gynecol Pathol
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Portugal