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Novel indole and triazole based hybrid molecules exhibit potent anti-adipogenic and antidyslipidemic activity by activating Wnt3a/ß-catenin pathway.
Rajan, Sujith; Puri, Surendra; Kumar, Durgesh; Babu, Madala Hari; Shankar, Kripa; Varshney, Salil; Srivastava, Ankita; Gupta, Abhishek; Reddy, M Sridhar; Gaikwad, Anil N.
Afiliação
  • Rajan S; Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow 226031, India; Academy of Scientific and Innovative Research, CSIR-CDRI, India.
  • Puri S; Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow 226031, India.
  • Kumar D; Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow 226031, India; Academy of Scientific and Innovative Research, CSIR-CDRI, India.
  • Babu MH; Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow 226031, India.
  • Shankar K; Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow 226031, India.
  • Varshney S; Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow 226031, India; Academy of Scientific and Innovative Research, CSIR-CDRI, India.
  • Srivastava A; Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow 226031, India; Academy of Scientific and Innovative Research, CSIR-CDRI, India.
  • Gupta A; Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow 226031, India.
  • Reddy MS; Division of Medicinal and Process Chemistry, CSIR-Central Drug Research Institute, Lucknow 226031, India. Electronic address: msreddy@cdri.res.in.
  • Gaikwad AN; Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow 226031, India; Academy of Scientific and Innovative Research, CSIR-CDRI, India. Electronic address: anil_gaikwad@cdri.res.in.
Eur J Med Chem ; 143: 1345-1360, 2018 Jan 01.
Article em En | MEDLINE | ID: mdl-29153558
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Triazóis / Desenho de Fármacos / Dislipidemias / Adipogenia / Via de Sinalização Wnt / Indóis Limite: Animals / Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Índia
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Triazóis / Desenho de Fármacos / Dislipidemias / Adipogenia / Via de Sinalização Wnt / Indóis Limite: Animals / Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Índia