PERK leads a hub dictating pancreatic ß cell homoeostasis.
Biol Cell
; 110(2): 27-32, 2018 Feb.
Article
em En
| MEDLINE
| ID: mdl-29168198
ABSTRACT
In humans, the pathogenesis of diabetes is characterised by two major pancreatic ß cell defects a reduction in ß cell mass and the failure of ß cells to produce enough insulin. Over the past two decades, multiple studies involving cell cultures, animal models and human subjects have established the importance of the protein kinase RNA-like endoplasmic reticulum kinase (PERK) in the adaptive functional capacity of pancreatic ß cells during embryonic development and into adulthood. In this review, we will highlight major findings identifying PERK as a crucial player in ß cell physiology and in diabetes.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Osteocondrodisplasias
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Fator de Iniciação 2 em Eucariotos
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EIF-2 Quinase
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Diabetes Mellitus Tipo 1
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Diabetes Mellitus Tipo 2
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Epífises
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Células Secretoras de Insulina
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Homeostase
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Biol Cell
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Canadá