Expression of iron-related proteins in feline and canine mammary gland reveals unexpected accumulation of iron.
Biotech Histochem
; 92(8): 584-594, 2017.
Article
em En
| MEDLINE
| ID: mdl-29172705
ABSTRACT
Dysregulation of cellular iron homeostasis in human breast cancer is reflected by the altered expression of regulatory proteins. The expressions of iron-related proteins in the mammary glands of cats and dogs have not been assessed. We evaluated the expressions of ferritin, ferroportin, hepcidin and transferrin receptor 1 in benign and malignant mammary gland lesions in cats and dogs. Iron deposition was detected using Perls' Prussian blue staining. We found no major differences in the expression of iron-related proteins between benign and malignant mammary gland lesions in either cats or dogs; however, these species exhibited accumulation of iron in benign lesions. Our findings provide an explanation for the absence of higher iron requirements by tumor cells in these animals. Further investigation of local iron homeostasis in cats and dogs and differences in their physiology compared to human breast cancer is required.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Mamárias Animais
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Proteínas Reguladoras de Ferro
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Ferro
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Glândulas Mamárias Animais
Limite:
Animals
Idioma:
En
Revista:
Biotech Histochem
Assunto da revista:
HISTOCITOQUIMICA
Ano de publicação:
2017
Tipo de documento:
Article