AP-4 mediates export of ATG9A from the <i>trans</i>-Golgi network to promote autophagosome formation.

Mattera, Rafael; Park, Sang Yoon; De Pace, Raffaella; Guardia, Carlos M; Bonifacino, Juan S

AP-4 mediates export of ATG9A from the trans-Golgi network to promote autophagosome formation.

Mattera, Rafael; Park, Sang Yoon; De Pace, Raffaella; Guardia, Carlos M; Bonifacino, Juan S.

Afiliação

Mattera R; Cell Biology and Neurobiology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892.
Park SY; Cell Biology and Neurobiology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892.
De Pace R; Cell Biology and Neurobiology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892.
Guardia CM; Cell Biology and Neurobiology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892.
Bonifacino JS; Cell Biology and Neurobiology Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892 juan.bonifacino@nih.gov.

Proc Natl Acad Sci U S A ; 114(50): E10697-E10706, 2017 12 12.

Article em En | MEDLINE | ID: mdl-29180427

Assuntos

Complexo 4 de Proteínas Adaptadoras/metabolismo; Autofagossomos/metabolismo; Proteínas Relacionadas à Autofagia/metabolismo; Complexo de Golgi/metabolismo; Proteínas de Membrana/metabolismo; Proteínas de Transporte Vesicular/metabolismo; Complexo 4 de Proteínas Adaptadoras/genética; Proteínas Adaptadoras de Transporte Vesicular/metabolismo; Motivos de Aminoácidos; Animais; Autofagia; Linhagem Celular Tumoral; Técnicas de Silenciamento de Genes; Células HeLa; Humanos; Camundongos; Camundongos Endogâmicos C57BL; Proteínas Associadas aos Microtúbulos/metabolismo; Modelos Moleculares; Paraplegia Espástica Hereditária/genética; Paraplegia Espástica Hereditária/metabolismo

Palavras-chave

AP-4; ATG9A; adaptor protein complexes; autophagy; protein sorting

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Transporte Vesicular / Complexo 4 de Proteínas Adaptadoras / Autofagossomos / Proteínas Relacionadas à Autofagia / Complexo de Golgi / Proteínas de Membrana Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2017 Tipo de documento: Article

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