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Discovery and Biological Evaluation of Potent and Selective N-Methylene Saccharin-Derived Inhibitors for Rhomboid Intramembrane Proteases.
Goel, Parul; Jumpertz, Thorsten; Mikles, David C; Tichá, Anezka; Nguyen, Minh T N; Verhelst, Steven; Hubalek, Martin; Johnson, Darren C; Bachovchin, Daniel A; Ogorek, Isabella; Pietrzik, Claus U; Strisovsky, Kvido; Schmidt, Boris; Weggen, Sascha.
Afiliação
  • Goel P; Department of Neuropathology, Heinrich-Heine University Duesseldorf , Moorenstrasse 5, 40225 Duesseldorf, Germany.
  • Jumpertz T; Clemens Schoepf Institute for Organic Chemistry and Biochemistry, Technical University of Darmstadt , Alarich-Weiss-Strasse 4-8, 64287 Darmstadt, Germany.
  • Mikles DC; Department of Neuropathology, Heinrich-Heine University Duesseldorf , Moorenstrasse 5, 40225 Duesseldorf, Germany.
  • Tichá A; Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic , Flemingovo n. 2, 166 10 Praha 6, Czech Republic.
  • Nguyen MTN; Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic , Flemingovo n. 2, 166 10 Praha 6, Czech Republic.
  • Verhelst S; Chemical Proteomics Group, Leibnitz Institute for Analytical Sciences (ISAS) e.V. , Otto-Hahn-Strasse 6b, 44227 Dortmund, Germany.
  • Hubalek M; Chemical Proteomics Group, Leibnitz Institute for Analytical Sciences (ISAS) e.V. , Otto-Hahn-Strasse 6b, 44227 Dortmund, Germany.
  • Johnson DC; Laboratory of Chemical Biology, Department of Cellular and Molecular Medicine, University of Leuven , Herestraat 49, Box 802, 3000 Leuven, Belgium.
  • Bachovchin DA; Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic , Flemingovo n. 2, 166 10 Praha 6, Czech Republic.
  • Ogorek I; Chemical Biology Program, Memorial Sloan Kettering Cancer Center , 1275 York Avenue, Box 428, New York, New York 10065, United States.
  • Pietrzik CU; Chemical Biology Program, Memorial Sloan Kettering Cancer Center , 1275 York Avenue, Box 428, New York, New York 10065, United States.
  • Strisovsky K; Department of Neuropathology, Heinrich-Heine University Duesseldorf , Moorenstrasse 5, 40225 Duesseldorf, Germany.
  • Schmidt B; Institute for Pathobiochemistry, University Medical Center of the Johannes Gutenberg University Mainz , Duesbergweg 6, 55128 Mainz, Germany.
  • Weggen S; Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic , Flemingovo n. 2, 166 10 Praha 6, Czech Republic.
Biochemistry ; 56(51): 6713-6725, 2017 12 26.
Article em En | MEDLINE | ID: mdl-29185711
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sacarina / Desenho de Fármacos / Inibidores de Serina Proteinase / Serina Proteases Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Biochemistry Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Alemanha
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sacarina / Desenho de Fármacos / Inibidores de Serina Proteinase / Serina Proteases Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Biochemistry Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Alemanha