Neuromuscular Junction Formation, Aging, and Disorders.
Annu Rev Physiol
; 80: 159-188, 2018 02 10.
Article
em En
| MEDLINE
| ID: mdl-29195055
ABSTRACT
Synapses, the fundamental unit in neuronal circuits, are critical for learning and memory, perception, thinking, and reaction. The neuromuscular junction (NMJ) is a synapse formed between motoneurons and skeletal muscle fibers that is covered by Schwann cells (SCs). It is essential for controlling muscle contraction. NMJ formation requires intimate interactions among motoneurons, muscles, and SCs. Deficits in NMJ formation and maintenance cause neuromuscular disorders, including congenital myasthenic syndrome and myasthenia gravis. NMJ decline occurs in aged animals and may appear before clinical presentation of motoneuron disorders such as amyotrophic lateral sclerosis. We review recent findings in NMJ formation, maintenance, neuromuscular disorders, and aging of the NMJ, focusing on communications among motoneurons, muscles and SCs, and underlying mechanisms.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
/
Neurônios Motores
/
Doenças Neuromusculares
/
Junção Neuromuscular
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Annu Rev Physiol
Ano de publicação:
2018
Tipo de documento:
Article