Identifying and Targeting Sporadic Oncogenic Genetic Aberrations in Mouse Models of Triple-Negative Breast Cancer.

Liu, Hui; Murphy, Charles J; Karreth, Florian A; Emdal, Kristina B; White, Forest M; Elemento, Olivier; Toker, Alex; Wulf, Gerburg M; Cantley, Lewis C

Liu, Hui; Murphy, Charles J; Karreth, Florian A; Emdal, Kristina B; White, Forest M; Elemento, Olivier; Toker, Alex; Wulf, Gerburg M; Cantley, Lewis C.

Afiliação

Liu H; Department of Pathology, and Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Murphy CJ; Institute for Computational Biomedicine, Weill Cornell Medical College, New York, New York.
Karreth FA; Meyer Cancer Center, Weill Cornell Medicine, New York, New York.
Emdal KB; Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
White FM; Department of Biological Engineering, Koch Institute for Integrative Cancer Research, MIT, Cambridge, Massachusetts.
Elemento O; Department of Biological Engineering, Koch Institute for Integrative Cancer Research, MIT, Cambridge, Massachusetts.
Toker A; Institute for Computational Biomedicine, Weill Cornell Medical College, New York, New York.
Wulf GM; Department of Pathology, and Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Cantley LC; Department of Pathology, and Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, and Ludwig Center at Harvard, Boston, Massachusetts.

Cancer Discov ; 8(3): 354-369, 2018 03.

Article em En | MEDLINE | ID: mdl-29203461

Assuntos

Neoplasias Mamárias Experimentais/genética; Mutação; Neoplasias de Mama Triplo Negativas/genética; Animais; Proteína BRCA1; Feminino; Fusão Gênica; Humanos; Sistema de Sinalização das MAP Quinases/genética; Neoplasias Mamárias Experimentais/tratamento farmacológico; Camundongos Mutantes; Fosfatidilinositol 3-Quinases/genética; Fosfatidilinositol 3-Quinases/metabolismo; Proteínas Proto-Oncogênicas c-raf/genética; Proteínas Proto-Oncogênicas c-raf/metabolismo; Receptor Tipo 2 de Fator de Crescimento de Fibroblastos/genética; Receptor Tipo 2 de Fator de Crescimento de Fibroblastos/metabolismo; Análise de Sequência de RNA; Neoplasias de Mama Triplo Negativas/tratamento farmacológico; Proteína Supressora de Tumor p53/genética; Proteínas Supressoras de Tumor/genética; Sequenciamento do Exoma

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias de Mama Triplo Negativas / Neoplasias Mamárias Experimentais / Mutação Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: Cancer Discov Ano de publicação: 2018 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google