Collective effects of common single nucleotide polymorphisms and genetic risk prediction in type 1 diabetes.
Clin Genet
; 93(5): 1069-1074, 2018 05.
Article
em En
| MEDLINE
| ID: mdl-29220073
ABSTRACT
Type 1 diabetes (T1D) is a common autoimmune disease and may be related to multiple genetic and environmental risk factors. Previous genetic studies have focused on looking for individual polymorphic risk variants. Here, we studied the overall levels of genetic diversity in T1D patients by making use of a previously published study including 1865 cases and 2828 reference samples with genotyping data for 500 K common single nucleotide polymorphisms (SNPs). We determined the minor allele (MA) status of each SNP in the reference samples and calculated the total number of MAs or minor allele contents (MAC) of each individual. We found the average MAC of cases to be greater than that of the reference samples. By focusing on MAs with strong linkage to cases, we further identified a set of 112 SNPs that could predict 19.19% of cases. These results suggest that overall genetic variation over a threshold level may be a risk factor in T1D and provide a new genetic method for predicting the disorder.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Medição de Risco
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Predisposição Genética para Doença
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Polimorfismo de Nucleotídeo Único
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Diabetes Mellitus Tipo 1
Tipo de estudo:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Female
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Humans
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Male
Idioma:
En
Revista:
Clin Genet
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
China