Diabetes as risk factor for pancreatic cancer: Hyperglycemia promotes epithelial-mesenchymal-transition and stem cell properties in pancreatic ductal epithelial cells.

Rahn, Sascha; Zimmermann, Vivien; Viol, Fabrice; Knaack, Hendrike; Stemmer, Kerstin; Peters, Lena; Lenk, Lennart; Ungefroren, Hendrik; Saur, Dieter; Schäfer, Heiner; Helm, Ole; Sebens, Susanne

Rahn, Sascha; Zimmermann, Vivien; Viol, Fabrice; Knaack, Hendrike; Stemmer, Kerstin; Peters, Lena; Lenk, Lennart; Ungefroren, Hendrik; Saur, Dieter; Schäfer, Heiner; Helm, Ole; Sebens, Susanne.

Afiliação

Rahn S; Institute for Experimental Cancer Research, Christian-Albrechts-University Kiel (CAU) and University Medical Center Schleswig-Holstein (UKSH) Campus Kiel, Kiel, Germany.
Zimmermann V; Institute for Experimental Cancer Research, Christian-Albrechts-University Kiel (CAU) and University Medical Center Schleswig-Holstein (UKSH) Campus Kiel, Kiel, Germany.
Viol F; Department of Medicine I, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Knaack H; Institute for Experimental Cancer Research, Christian-Albrechts-University Kiel (CAU) and University Medical Center Schleswig-Holstein (UKSH) Campus Kiel, Kiel, Germany.
Stemmer K; Helmholtz Zentrum München, Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), Neuherberg, Germany.
Peters L; Institute for Experimental Cancer Research, Christian-Albrechts-University Kiel (CAU) and University Medical Center Schleswig-Holstein (UKSH) Campus Kiel, Kiel, Germany.
Lenk L; Institute for Experimental Cancer Research, Christian-Albrechts-University Kiel (CAU) and University Medical Center Schleswig-Holstein (UKSH) Campus Kiel, Kiel, Germany.
Ungefroren H; Department of General Surgery and Thoracic Surgery, UKSH Campus Kiel, Germany; First Department of Medicine, UKSH Campus Lübeck, Lübeck, Germany.
Saur D; II. Medizinische Klinik und Poliklinik, Klinikum Rechts der Isar, Technical University Munich, Munich, Germany.
Schäfer H; Institute for Experimental Cancer Research, Christian-Albrechts-University Kiel (CAU) and University Medical Center Schleswig-Holstein (UKSH) Campus Kiel, Kiel, Germany.
Helm O; Institute for Experimental Cancer Research, Christian-Albrechts-University Kiel (CAU) and University Medical Center Schleswig-Holstein (UKSH) Campus Kiel, Kiel, Germany.
Sebens S; Institute for Experimental Cancer Research, Christian-Albrechts-University Kiel (CAU) and University Medical Center Schleswig-Holstein (UKSH) Campus Kiel, Kiel, Germany. Electronic address: susanne.sebens@email.uni-kiel.de.

Cancer Lett ; 415: 129-150, 2018 02 28.

Article em En | MEDLINE | ID: mdl-29222037

Assuntos

Diabetes Mellitus Tipo 2/genética; Células Epiteliais/metabolismo; Transição Epitelial-Mesenquimal/genética; Hiperglicemia/genética; Células-Tronco Neoplásicas/metabolismo; Neoplasias Pancreáticas/genética; Animais; Linhagem Celular; Linhagem Celular Tumoral; Diabetes Mellitus Tipo 2/complicações; Diabetes Mellitus Tipo 2/metabolismo; Feminino; Regulação Neoplásica da Expressão Gênica; Glucose/farmacologia; Humanos; Hiperglicemia/metabolismo; Masculino; Camundongos Endogâmicos C57BL; Células-Tronco Neoplásicas/efeitos dos fármacos; Ductos Pancreáticos/metabolismo; Neoplasias Pancreáticas/complicações; Neoplasias Pancreáticas/metabolismo; Fatores de Risco; Fator de Crescimento Transformador beta1/metabolismo

Palavras-chave

Cancer stemness; Diabetes; EMT; Glucose; Pancreatic cancer

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Células-Tronco Neoplásicas / Diabetes Mellitus Tipo 2 / Células Epiteliais / Transição Epitelial-Mesenquimal / Hiperglicemia Tipo de estudo: Etiology_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: Cancer Lett Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Alemanha

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