Phosphorylation of the synaptonemal complex protein SYP-1 promotes meiotic chromosome segregation.
J Cell Biol
; 217(2): 555-570, 2018 02 05.
Article
em En
| MEDLINE
| ID: mdl-29222184
ABSTRACT
Chromosomes that have undergone crossing over in meiotic prophase must maintain sister chromatid cohesion somewhere along their length between the first and second meiotic divisions. Although many eukaryotes use the centromere as a site to maintain cohesion, the holocentric organism Caenorhabditis elegans instead creates two chromosome domains of unequal length termed the short arm and long arm, which become the first and second site of cohesion loss at meiosis I and II. The mechanisms that confer distinct functions to the short and long arm domains remain poorly understood. Here, we show that phosphorylation of the synaptonemal complex protein SYP-1 is required to create these domains. Once crossover sites are designated, phosphorylated SYP-1 and PLK-2 become cooperatively confined to short arms and guide phosphorylated histone H3 and the chromosomal passenger complex to the site of meiosis I cohesion loss. Our results show that PLK-2 and phosphorylated SYP-1 ensure creation of the short arm subdomain, promoting disjunction of chromosomes in meiosis I.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Complexo Sinaptonêmico
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Proteínas Nucleares
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Segregação de Cromossomos
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Proteínas de Caenorhabditis elegans
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Meiose
Limite:
Animals
Idioma:
En
Revista:
J Cell Biol
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Japão