Murine transgenic embryonic stem cell lines for the investigation of sinoatrial node-related molecular pathways.
Stem Cell Res
; 25: 278-282, 2017 12.
Article
em En
| MEDLINE
| ID: mdl-29246574
The elucidation of molecular mechanisms that restrict the potential of pluripotent stem cells and promote cardiac lineage differentiation is of crucial relevance, since embryonic stem cells (ESCs) hold great potential for cell based heart therapies. The homeodomain transcription factor Shox2 is essential for the development and proper function of the native cardiac pacemaker, the sinoatrial node. This prompted us to develop a cardiac differentiation model using ESC lines isolated from blastocysts of Shox2-deficient mice. The established cell model provides a fundamental basis for the investigation of molecular pathways under physiological and pathophysiological conditions for evaluating novel therapeutic approaches.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Nó Sinoatrial
/
Miócitos Cardíacos
/
Células-Tronco Embrionárias
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Stem Cell Res
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Alemanha