A centrosomal scaffold shows some self-control.
J Biol Chem
; 292(50): 20410-20411, 2017 12 15.
Article
em En
| MEDLINE
| ID: mdl-29247130
ABSTRACT
The scaffolding protein AKAP350A is known to localize to the centrosome and the Golgi, but the molecular details of its function at the centrosome remain elusive. Using structure-function analyses, protein interaction assays, and super-resolution microscopy, Kolobova et al. now identify AKAP350A's specific location and protein partners at the centrosome. The authors further define an autoregulatory mechanism that likely controls AKAP350A's ability to nucleate microtubule growth.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Modelos Moleculares
/
Centrossomo
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Centro Organizador dos Microtúbulos
/
Proteínas do Citoesqueleto
/
Proteínas de Ancoragem à Quinase A
Limite:
Animals
/
Humans
Idioma:
En
Revista:
J Biol Chem
Ano de publicação:
2017
Tipo de documento:
Article