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Intrinsic Immunity Shapes Viral Resistance of Stem Cells.
Wu, Xianfang; Dao Thi, Viet Loan; Huang, Yumin; Billerbeck, Eva; Saha, Debjani; Hoffmann, Hans-Heinrich; Wang, Yaomei; Silva, Luis A Vale; Sarbanes, Stephanie; Sun, Tony; Andrus, Linda; Yu, Yingpu; Quirk, Corrine; Li, Melody; MacDonald, Margaret R; Schneider, William M; An, Xiuli; Rosenberg, Brad R; Rice, Charles M.
Afiliação
  • Wu X; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA.
  • Dao Thi VL; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA.
  • Huang Y; Laboratory of Membrane Biology, New York Blood Center, New York, NY 10065, USA; Department of Hematology, the First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan 450001, China.
  • Billerbeck E; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA.
  • Saha D; Program in Immunogenomics, The Rockefeller University, New York, NY 10065, USA.
  • Hoffmann HH; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA.
  • Wang Y; Laboratory of Membrane Biology, New York Blood Center, New York, NY 10065, USA; School of Life Sciences, Zhengzhou University, Zhengzhou, Henan 450001, China.
  • Silva LAV; Department of Biology, New York University, New York, NY 10003, USA.
  • Sarbanes S; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA.
  • Sun T; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA.
  • Andrus L; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA.
  • Yu Y; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA.
  • Quirk C; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA.
  • Li M; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA.
  • MacDonald MR; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA.
  • Schneider WM; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA.
  • An X; Laboratory of Membrane Biology, New York Blood Center, New York, NY 10065, USA; School of Life Sciences, Zhengzhou University, Zhengzhou, Henan 450001, China.
  • Rosenberg BR; Program in Immunogenomics, The Rockefeller University, New York, NY 10065, USA.
  • Rice CM; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY 10065, USA. Electronic address: ricec@rockefeller.edu.
Cell ; 172(3): 423-438.e25, 2018 01 25.
Article em En | MEDLINE | ID: mdl-29249360
ABSTRACT
Stem cells are highly resistant to viral infection compared to their differentiated progeny; however, the mechanism is mysterious. Here, we analyzed gene expression in mammalian stem cells and cells at various stages of differentiation. We find that, conserved across species, stem cells express a subset of genes previously classified as interferon (IFN) stimulated genes (ISGs) but that expression is intrinsic, as stem cells are refractory to interferon. This intrinsic ISG expression varies in a cell-type-specific manner, and many ISGs decrease upon differentiation, at which time cells become IFN responsive, allowing induction of a broad spectrum of ISGs by IFN signaling. Importantly, we show that intrinsically expressed ISGs protect stem cells against viral infection. We demonstrate the in vivo importance of intrinsic ISG expression for protecting stem cells and their differentiation potential during viral infection. These findings have intriguing implications for understanding stem cell biology and the evolution of pathogen resistance.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Viroses / Células-Tronco Pluripotentes / Imunidade Inata Limite: Animals / Female / Humans / Male Idioma: En Revista: Cell Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Viroses / Células-Tronco Pluripotentes / Imunidade Inata Limite: Animals / Female / Humans / Male Idioma: En Revista: Cell Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos