LEM4/ANKLE-2 deficiency impairs post-mitotic re-localization of BAF, LAP2&#945; and LaminA to the nucleus, causes nuclear envelope instability in telophase and leads to hyperploidy in HeLa cells.

Snyers, Luc; Erhart, Renate; Laffer, Sylvia; Pusch, Oliver; Weipoltshammer, Klara; Schöfer, Christian

LEM4/ANKLE-2 deficiency impairs post-mitotic re-localization of BAF, LAP2α and LaminA to the nucleus, causes nuclear envelope instability in telophase and leads to hyperploidy in HeLa cells.

Snyers, Luc; Erhart, Renate; Laffer, Sylvia; Pusch, Oliver; Weipoltshammer, Klara; Schöfer, Christian.

Afiliação

Snyers L; Department of Cell and Developmental Biology, Center for Anatomy and Cell Biology, Medical University of Vienna, Schwarzspanierstrasse 17, Vienna, 1090, Austria. Electronic address: luc.snyers@meduniwien.ac.at.
Erhart R; Department of Cell and Developmental Biology, Center for Anatomy and Cell Biology, Medical University of Vienna, Schwarzspanierstrasse 17, Vienna, 1090, Austria.
Laffer S; Department of Cell and Developmental Biology, Center for Anatomy and Cell Biology, Medical University of Vienna, Schwarzspanierstrasse 17, Vienna, 1090, Austria.
Pusch O; Department of Cell and Developmental Biology, Center for Anatomy and Cell Biology, Medical University of Vienna, Schwarzspanierstrasse 17, Vienna, 1090, Austria.
Weipoltshammer K; Department of Cell and Developmental Biology, Center for Anatomy and Cell Biology, Medical University of Vienna, Schwarzspanierstrasse 17, Vienna, 1090, Austria.
Schöfer C; Department of Cell and Developmental Biology, Center for Anatomy and Cell Biology, Medical University of Vienna, Schwarzspanierstrasse 17, Vienna, 1090, Austria.

Eur J Cell Biol ; 97(1): 63-74, 2018 Jan.

Article em En | MEDLINE | ID: mdl-29254732

Assuntos

Núcleo Celular/patologia; Instabilidade Cromossômica; Proteínas de Membrana/metabolismo; Mitose; Membrana Nuclear/patologia; Proteínas Nucleares/metabolismo; Ploidias; Telófase; Sistemas CRISPR-Cas; Núcleo Celular/metabolismo; Proteínas de Ligação a DNA/metabolismo; Células HeLa; Humanos; Lamina Tipo A/metabolismo; Membrana Nuclear/metabolismo

Palavras-chave

BAF; LEM-domain; Mitosis; Nuclear envelope

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ploidias / Telófase / Proteínas Nucleares / Núcleo Celular / Instabilidade Cromossômica / Proteínas de Membrana / Mitose / Membrana Nuclear Tipo de estudo: Etiology_studies Limite: Humans Idioma: En Revista: Eur J Cell Biol Ano de publicação: 2018 Tipo de documento: Article

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