A fluorescent activatable probe for imaging intracellular Mg<sup>2+</sup> .

Treadwell, Ryan; de Moliner, Fabio; Subiros-Funosas, Ramon; Hurd, Toby; Knox, Kirsten; Vendrell, Marc

A fluorescent activatable probe for imaging intracellular Mg²⁺ .

Treadwell, Ryan; de Moliner, Fabio; Subiros-Funosas, Ramon; Hurd, Toby; Knox, Kirsten; Vendrell, Marc.

Afiliação

Treadwell R; Medical Research Council Centre for Inflammation Research, The University of Edinburgh, EH16 4TJ Edinburgh, UK. marc.vendrell@ed.ac.uk.

Org Biomol Chem ; 16(2): 239-244, 2018 01 03.

Article em En | MEDLINE | ID: mdl-29256562

ABSTRACT

ABSTRACT

An activatable BODIPY probe for in vitro detection and fluorescence cell imaging of free Mg2+ without interference from Ca2+ is described. Fluorescence amplification of the probe is observed upon detection of physiological concentrations of Mg2+ due to reduced rotation of the fluorophore and effective chelation by a quinolizine-based core.

Assuntos

Corantes Fluorescentes/química; Magnésio/análise; Imagem Molecular/métodos; Animais; Quelantes; Humanos; Quinolizinas; Rotação

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Imagem Molecular / Corantes Fluorescentes / Magnésio Limite: Animals / Humans Idioma: En Revista: Org Biomol Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Reino Unido

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