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Synthesis and biological evaluation of novel thiazole- VX-809 hybrid derivatives as F508del correctors by QSAR-based filtering tools.
Liessi, Nara; Cichero, Elena; Pesce, Emanuela; Arkel, Maria; Salis, Annalisa; Tomati, Valeria; Paccagnella, Matteo; Damonte, Gianluca; Tasso, Bruno; Galietta, Luis J V; Pedemonte, Nicoletta; Fossa, Paola; Millo, Enrico.
Afiliação
  • Liessi N; Department of Experimental Medicine, Section of Biochemistry, University of Genoa, Viale Benedetto XV 1, 16132 Genoa, Italy; Center of Excellence for Biomedical Research (CEBR), University of Genoa, Viale Benedetto XV 9, 16132 Genoa, Italy.
  • Cichero E; Department of Pharmacy, Section of Medicinal Chemistry, School of Medical and Pharmaceutical Sciences, University of Genoa, Viale Benedetto XV, 3, 16132 Genoa, Italy.
  • Pesce E; U.O.C. Genetica Medica, Istituto Giannina Gaslini, Genova, Italy.
  • Arkel M; Department of Experimental Medicine, Section of Biochemistry, University of Genoa, Viale Benedetto XV 1, 16132 Genoa, Italy.
  • Salis A; Center of Excellence for Biomedical Research (CEBR), University of Genoa, Viale Benedetto XV 9, 16132 Genoa, Italy.
  • Tomati V; U.O.C. Genetica Medica, Istituto Giannina Gaslini, Genova, Italy.
  • Paccagnella M; Department of Experimental Medicine, Section of Biochemistry, University of Genoa, Viale Benedetto XV 1, 16132 Genoa, Italy.
  • Damonte G; Department of Experimental Medicine, Section of Biochemistry, University of Genoa, Viale Benedetto XV 1, 16132 Genoa, Italy; Center of Excellence for Biomedical Research (CEBR), University of Genoa, Viale Benedetto XV 9, 16132 Genoa, Italy.
  • Tasso B; Department of Pharmacy, Section of Medicinal Chemistry, School of Medical and Pharmaceutical Sciences, University of Genoa, Viale Benedetto XV, 3, 16132 Genoa, Italy.
  • Galietta LJV; U.O.C. Genetica Medica, Istituto Giannina Gaslini, Genova, Italy.
  • Pedemonte N; U.O.C. Genetica Medica, Istituto Giannina Gaslini, Genova, Italy.
  • Fossa P; Department of Pharmacy, Section of Medicinal Chemistry, School of Medical and Pharmaceutical Sciences, University of Genoa, Viale Benedetto XV, 3, 16132 Genoa, Italy. Electronic address: fossa@difar.unige.it.
  • Millo E; Department of Experimental Medicine, Section of Biochemistry, University of Genoa, Viale Benedetto XV 1, 16132 Genoa, Italy; Center of Excellence for Biomedical Research (CEBR), University of Genoa, Viale Benedetto XV 9, 16132 Genoa, Italy. Electronic address: enrico.millo@unige.it.
Eur J Med Chem ; 144: 179-200, 2018 Jan 20.
Article em En | MEDLINE | ID: mdl-29272749
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tiazóis / Regulador de Condutância Transmembrana em Fibrose Cística / Benzodioxóis / Aminopiridinas / Mutação Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Itália
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tiazóis / Regulador de Condutância Transmembrana em Fibrose Cística / Benzodioxóis / Aminopiridinas / Mutação Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Itália