Fluorescently Labeled Morphine Derivatives for Bioimaging Studies.
J Med Chem
; 61(3): 1316-1329, 2018 02 08.
Article
em En
| MEDLINE
| ID: mdl-29291353
ABSTRACT
Opioids, like morphine, are the mainstay analgesics for the treatment and control of pain. Despite this, they often exhibit severe side effects that limit dose; patients often become tolerant and dependent on these drugs, which remains a major health concern. The analgesic actions of opioids are primarily mediated via the µ-opioid receptor, a member of the G protein-coupled receptor superfamily. Thus far, development of small molecule fluorescent ligands for this receptor has resulted in antagonists, somewhat limiting the use of these probes. Herein, we describe our work on the development of a small molecule fluorescent probe based on the clinically used opiate morphine and initial characterization of its behavior in cell-based assays.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Imagem Molecular
/
Corantes Fluorescentes
/
Analgésicos Opioides
/
Morfina
Limite:
Humans
Idioma:
En
Revista:
J Med Chem
Assunto da revista:
QUIMICA
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Reino Unido