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Novel K-Ras G12C Switch-II Covalent Binders Destabilize Ras and Accelerate Nucleotide Exchange.
Nnadi, Chimno I; Jenkins, Meredith L; Gentile, Daniel R; Bateman, Leslie A; Zaidman, Daniel; Balius, Trent E; Nomura, Daniel K; Burke, John E; Shokat, Kevan M; London, Nir.
Afiliação
  • Nnadi CI; Department of Cellular and Molecular Pharmacology, Howard Hughes Medical Institute, University of California, San Francisco , San Francisco, California 94158, United States.
  • Jenkins ML; Department of Biochemistry and Microbiology. University of Victoria , Victoria, BC V8W 2Y2, Canada.
  • Gentile DR; Department of Cellular and Molecular Pharmacology, Howard Hughes Medical Institute, University of California, San Francisco , San Francisco, California 94158, United States.
  • Bateman LA; Departments of Chemistry, Molecular and Cell Biology, and Nutritional Sciences and Toxicology, University of California, Berkeley , Berkeley, California 94720, United States.
  • Zaidman D; Department of Organic Chemistry, The Weizmann Institute of Science , Rehovot, 7610001, Israel.
  • Balius TE; Department of Pharmaceutical Chemistry, University of California, San Francisco , San Francisco, California 94158, United States.
  • Nomura DK; Departments of Chemistry, Molecular and Cell Biology, and Nutritional Sciences and Toxicology, University of California, Berkeley , Berkeley, California 94720, United States.
  • Burke JE; Department of Biochemistry and Microbiology. University of Victoria , Victoria, BC V8W 2Y2, Canada.
  • Shokat KM; Department of Cellular and Molecular Pharmacology, Howard Hughes Medical Institute, University of California, San Francisco , San Francisco, California 94158, United States.
  • London N; Department of Organic Chemistry, The Weizmann Institute of Science , Rehovot, 7610001, Israel.
J Chem Inf Model ; 58(2): 464-471, 2018 02 26.
Article em En | MEDLINE | ID: mdl-29320178
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas ras / Simulação de Acoplamento Molecular / Nucleotídeos Idioma: En Revista: J Chem Inf Model Assunto da revista: INFORMATICA MEDICA / QUIMICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas ras / Simulação de Acoplamento Molecular / Nucleotídeos Idioma: En Revista: J Chem Inf Model Assunto da revista: INFORMATICA MEDICA / QUIMICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos