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Computational Investigation of Environment-Noise Interaction in Single-Cell Organisms: The Merit of Expression Stochasticity Depends on the Quality of Environmental Fluctuations.
Lück, Anja; Klimmasch, Lukas; Großmann, Peter; Germerodt, Sebastian; Kaleta, Christoph.
Afiliação
  • Lück A; Department of Bioinformatics, Friedrich Schiller University, Jena, 07743, Germany.
  • Klimmasch L; Research Group Theoretical Systems Biology, Friedrich Schiller University, Jena, 07743, Germany.
  • Großmann P; Department of Bioinformatics, Friedrich Schiller University, Jena, 07743, Germany.
  • Germerodt S; Department of Bioinformatics, Friedrich Schiller University, Jena, 07743, Germany.
  • Kaleta C; Research Group Medical Systems Biology, Institute for Experimental Medicine, Christian-Albrechts-University, Kiel, 24105, Germany. c.kaleta@iem.uni-kiel.de.
Sci Rep ; 8(1): 333, 2018 01 10.
Article em En | MEDLINE | ID: mdl-29321537
Organisms need to adapt to changing environments and they do so by using a broad spectrum of strategies. These strategies include finding the right balance between expressing genes before or when they are needed, and adjusting the degree of noise inherent in gene expression. We investigated the interplay between different nutritional environments and the inhabiting organisms' metabolic and genetic adaptations by applying an evolutionary algorithm to an agent-based model of a concise bacterial metabolism. Our results show that constant environments and rapidly fluctuating environments produce similar adaptations in the organisms, making the predictability of the environment a major factor in determining optimal adaptation. We show that exploitation of expression noise occurs only in some types of fluctuating environment and is strongly dependent on the quality and availability of nutrients: stochasticity is generally detrimental in fluctuating environments and beneficial only at equal periods of nutrient availability and above a threshold environmental richness. Moreover, depending on the availability and nutritional value of nutrients, nutrient-dependent and stochastic expression are both strategies used to deal with environmental changes. Overall, we comprehensively characterize the interplay between the quality and periodicity of an environment and the resulting optimal deterministic and stochastic regulation strategies of nutrient-catabolizing pathways.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Adaptação Biológica / Meio Ambiente / Modelos Biológicos / Ruído Tipo de estudo: Prognostic_studies Idioma: En Revista: Sci Rep Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Alemanha

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Adaptação Biológica / Meio Ambiente / Modelos Biológicos / Ruído Tipo de estudo: Prognostic_studies Idioma: En Revista: Sci Rep Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Alemanha