The triglyceride-glucose index, an insulin resistance marker in newborns?
Eur J Pediatr
; 177(4): 513-520, 2018 Apr.
Article
em En
| MEDLINE
| ID: mdl-29350334
ABSTRACT
The study aims to assess the utility of the triglyceride-glucose index (TyG) as a marker of insulin resistance (IR) in neonates. TyG and the homeostatic model assessment (HOMA-IR) values were compared in 196 singleton, term normoweight and without distress newborns. A Decision Tree procedure (CHAID) was used to classify cases into groups or predict values of a dependent (Ln HOMA-IR) variable. Three nodes were drawn for TyG ≤ 6.7, > 6.7-7.8 and > 7.8 (p < 0.0001; F = 20.52). The predictability of those TyG values vs HOMA-IR was statistically significant (p < 0.0001). It was neither affected by gender (p = 0.084), glucose challenge test (p = 0.138) classifications nor by the TyG node* glucose challenge test and TyG node*gender interactions (p = 0.456 and p = 0.209, respectively). Glucose, HOMA-IR, and the triglyceride/HDL cholesterol ratio increased progressively from node 1 to 3 for TyG while QUICKI decreased. CONCLUSION:
In conclusion, TyG appears to be a suitable tool for identifying IR at birth, justifying the further insulin determination in those neonates. TyG ≥ 7.8 is recommended as cut-off point in neonates. The need for a follow-up study to confirm the TyG as early IR marker is desirable. WHAT IS KNOWN ⢠HOMA-IR and the triglyceride-glucose index (TyG) show a high correlation. ⢠The TyG has been used as an insulin resistance marker in adults. WHAT IS NEW ⢠This is the first study where TyG has been assessed in neonates. ⢠TyG appears to be a suitable and cheap tool for identifying insulin resistance at birth.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Triglicerídeos
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Glicemia
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Resistência à Insulina
/
Biomarcadores
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Female
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Humans
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Male
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Newborn
Idioma:
En
Revista:
Eur J Pediatr
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Espanha