Spexin as a neuroendocrine signal with emerging functions.
Gen Comp Endocrinol
; 265: 90-96, 2018 09 01.
Article
em En
| MEDLINE
| ID: mdl-29355530
ABSTRACT
Spexin (SPX), a novel peptide coevolved with the galanin/kisspeptin family, was first identified by bioinformatics prior to its protein purification/functional studies. Its mature peptide is highly conserved among different vertebrate classes. Based on the studies in mammals and fish models, SPX was found to be widely distributed at tissue level, secreted into systemic circulation, identified at notable levels in central nervous system and peripheral tissues, and has been confirmed/implicated in multiple functions in different tissues/organs, suggesting that SPX may serve as a neuroeândocrine signal with pleotropic functions. In this article, different isoforms of SPX and their binding with their cognate receptors GalR2 and GalR3, the biological functions of SPX reported in mammals including GI tract movement, energy balance and weight loss, fatty acid uptake, glucose homeostasis, nociception and cardiovascular/renal functions, as well as the recent findings in fish models regarding the role of SPX in reproduction and feeding control will be reviewed with interesting questions for future investigations.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Hormônios Peptídicos
/
Sistemas Neurossecretores
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Gen Comp Endocrinol
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
China