Construction of an oesophageal cancer-specific ceRNA network based on miRNA, lncRNA, and mRNA expression data.
World J Gastroenterol
; 24(1): 23-34, 2018 Jan 07.
Article
em En
| MEDLINE
| ID: mdl-29358879
ABSTRACT
AIM:
To explore the expression profiles of microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and mRNAs in oesophageal squamous cell carcinoma (ESCC) in order to construct an oesophageal cancer-specific competing endogenous RNA (ceRNA) network.METHODS:
In this work, the expression data of miRNAs, lncRNAs, and mRNAs in ESCC were obtained. An oesophageal cancer-specific ceRNA network was then constructed and investigated.RESULTS:
CeRNAs have the ability to reduce the targeting activity of miRNAs, leading to the de-repression of specific mRNAs with common miRNA response elements. CeRNA interactions have a critical effect in gene regulation and cancer development.CONCLUSION:
This study suggests a novel perspective on potential oesophageal cancer mechanisms as well as novel pathways for modulating ceRNA networks for treating cancers.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
RNA Mensageiro
/
RNA Neoplásico
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Neoplasias Esofágicas
/
Carcinoma de Células Escamosas
/
MicroRNAs
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Redes Reguladoras de Genes
/
RNA Longo não Codificante
Limite:
Humans
Idioma:
En
Revista:
World J Gastroenterol
Assunto da revista:
GASTROENTEROLOGIA
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
China