Drug metabolism in early infancy: opioids as an illustration.

Van Donge, Tamara; Mian, Paola; Tibboel, Dick; Van Den Anker, John; Allegaert, Karel

Van Donge, Tamara; Mian, Paola; Tibboel, Dick; Van Den Anker, John; Allegaert, Karel.

Afiliação

Van Donge T; a Intensive Care and Department of Paediatric Surgery , Erasmus MC-Sophia Children's Hospital , Rotterdam , The Netherlands.
Mian P; b Systems Biomedicine and Pharmacology , LACDR, Leiden University , Leiden , The Netherlands.
Tibboel D; a Intensive Care and Department of Paediatric Surgery , Erasmus MC-Sophia Children's Hospital , Rotterdam , The Netherlands.
Van Den Anker J; a Intensive Care and Department of Paediatric Surgery , Erasmus MC-Sophia Children's Hospital , Rotterdam , The Netherlands.
Allegaert K; a Intensive Care and Department of Paediatric Surgery , Erasmus MC-Sophia Children's Hospital , Rotterdam , The Netherlands.

Expert Opin Drug Metab Toxicol ; 14(3): 287-301, 2018 Mar.

Article em En | MEDLINE | ID: mdl-29363349

Assuntos

Analgésicos Opioides/administração & dosagem; Fentanila/administração & dosagem; Morfina/administração & dosagem; Fatores Etários; Analgésicos Opioides/farmacocinética; Peso Corporal; Citocromo P-450 CYP3A/metabolismo; Relação Dose-Resposta a Droga; Fentanila/farmacocinética; Glucuronosiltransferase/metabolismo; Humanos; Lactente; Modelos Biológicos; Morfina/farmacocinética; Farmacogenética

Palavras-chave

Enzyme maturation; fentanyl; infant; morphine; neonate; pharmacodynamics; population-pharmacokinetic modelling

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fentanila / Analgésicos Opioides / Morfina Tipo de estudo: Prognostic_studies Limite: Humans / Infant Idioma: En Revista: Expert Opin Drug Metab Toxicol Assunto da revista: METABOLISMO / TOXICOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Holanda

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