Liposomal Irinotecan Accumulates in Metastatic Lesions, Crosses the Blood-Tumor Barrier (BTB), and Prolongs Survival in an Experimental Model of Brain Metastases of Triple Negative Breast Cancer.

Mohammad, Afroz S; Griffith, Jessica I; Adkins, Chris E; Shah, Neal; Sechrest, Emily; Dolan, Emma L; Terrell-Hall, Tori B; Hendriks, Bart S; Lee, Helen; Lockman, Paul R

Mohammad, Afroz S; Griffith, Jessica I; Adkins, Chris E; Shah, Neal; Sechrest, Emily; Dolan, Emma L; Terrell-Hall, Tori B; Hendriks, Bart S; Lee, Helen; Lockman, Paul R.

Afiliação

Mohammad AS; School of Pharmacy, Department of Pharmaceutical Sciences, West Virginia University Health Sciences Center, 1 Medical Center Drive, Morgantown, West Virginia, 26506-9050, USA.
Griffith JI; School of Pharmacy, Department of Pharmaceutical Sciences, West Virginia University Health Sciences Center, 1 Medical Center Drive, Morgantown, West Virginia, 26506-9050, USA.
Adkins CE; School of Pharmacy, Department of Pharmaceutical Sciences, West Virginia University Health Sciences Center, 1 Medical Center Drive, Morgantown, West Virginia, 26506-9050, USA.
Shah N; School of Pharmacy, Department of Pharmaceutical Sciences, West Virginia University Health Sciences Center, 1 Medical Center Drive, Morgantown, West Virginia, 26506-9050, USA.
Sechrest E; School of Pharmacy, Department of Pharmaceutical Sciences, West Virginia University Health Sciences Center, 1 Medical Center Drive, Morgantown, West Virginia, 26506-9050, USA.
Dolan EL; School of Pharmacy, Department of Pharmaceutical Sciences, West Virginia University Health Sciences Center, 1 Medical Center Drive, Morgantown, West Virginia, 26506-9050, USA.
Terrell-Hall TB; School of Pharmacy, Department of Pharmaceutical Sciences, West Virginia University Health Sciences Center, 1 Medical Center Drive, Morgantown, West Virginia, 26506-9050, USA.
Hendriks BS; Merrimack Pharmaceuticals, Cambridge, Massachusetts, 02139, USA.
Lee H; Merrimack Pharmaceuticals, Cambridge, Massachusetts, 02139, USA.
Lockman PR; School of Pharmacy, Department of Pharmaceutical Sciences, West Virginia University Health Sciences Center, 1 Medical Center Drive, Morgantown, West Virginia, 26506-9050, USA. prlockman@hsc.wvu.edu.

Pharm Res ; 35(2): 31, 2018 Jan 09.

Article em En | MEDLINE | ID: mdl-29368289

Assuntos

Neoplasias Encefálicas/tratamento farmacológico; Encéfalo/metabolismo; Irinotecano/farmacocinética; Inibidores da Topoisomerase I/farmacocinética; Neoplasias de Mama Triplo Negativas/patologia; Animais; Encéfalo/patologia; Neoplasias Encefálicas/mortalidade; Neoplasias Encefálicas/secundário; Linhagem Celular Tumoral; Feminino; Humanos; Injeções Intravenosas; Irinotecano/uso terapêutico; Lipossomos; Camundongos; Camundongos Nus; Nanopartículas; Permeabilidade; Distribuição Tecidual; Inibidores da Topoisomerase I/uso terapêutico; Resultado do Tratamento; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

chemotherapy; enhanced permeation and retention; nanoparticles; permeability; pharmacokinetics

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encéfalo / Neoplasias Encefálicas / Inibidores da Topoisomerase I / Neoplasias de Mama Triplo Negativas / Irinotecano Limite: Animals / Female / Humans Idioma: En Revista: Pharm Res Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google