Influence of ABO blood group on von Willebrand factor tests in healthy Saudi blood donors.
Blood Coagul Fibrinolysis
; 29(2): 211-215, 2018 Mar.
Article
em En
| MEDLINE
| ID: mdl-29369083
ABSTRACT
Von Willebrand disease is a common bleeding disorder. The wide variation in von Willebrand factor (VWF) levels between and within normal individuals highlights the clinical challenge of defining its cutoff value. Although studies on the influence of ethnicity on ABO phenotypes and the levels of VWF have been carried out on different ethnicities, there is a lack of such data among Arab population. We aimed to evaluate the correlation of ABO phenotypes with all the parameters of the minimal test panel of VWF including VWF antigen, VWF activity using the ristocetin cofactor and the collagen binding activity assays, and factor VIII coagulant activity (VWFAg, VWFRCo, VWFCB and FVIIIC) tested in a normal Arab population, and to estimate ABO-specific normal reference range. Blood samples were collected from 87 healthy donors in Riyadh to determine levels of factor VIII and VWF panel between the various ABO phenotypes. The highest mean values of factor VIIIââC (128âU/dl), VWFââAg (125âU/dl), VWFââRCo (109âU/dl) and VWFââCB (91âU/dl) were observed with type AB and the lowest mean values of factor VIIIââC (81âU/dl), VWFââAg (85âU/dl), VWFââRCo (73âU/dl) and VWFââCB (70âU/dl) corresponded to type O. ABO phenotypes significantly influence plasma levels of VWF parameters in Arab nations as seen with other ethnicity. Hence, ABO-specific normal ranges of the minimal test panel of VWF and factor VIIIââC are essential for the appropriate prediction of mild von Willebrand disease. Further study including a larger categorized sample size is required to generalize the test panel on the Arab population.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sistema ABO de Grupos Sanguíneos
/
Fator de von Willebrand
Tipo de estudo:
Prognostic_studies
Limite:
Adolescent
/
Adult
/
Aged
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Female
/
Humans
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Male
/
Middle aged
País/Região como assunto:
Asia
Idioma:
En
Revista:
Blood Coagul Fibrinolysis
Assunto da revista:
ANGIOLOGIA
/
HEMATOLOGIA
Ano de publicação:
2018
Tipo de documento:
Article