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Terretonin N: A New Meroterpenoid from Nocardiopsis sp.
Hamed, Abdelaaty; Abdel-Razek, Ahmed S; Frese, Marcel; Stammler, Hans Georg; El-Haddad, Atef F; Ibrahim, Tarek M A; Sewald, Norbert; Shaaban, Mohamed.
Afiliação
  • Hamed A; Organic and Bioorganic Chemistry, Faculty of Chemistry, Bielefeld University, D-33501 Bielefeld, Germany. abdohamed481@yahoo.com.
  • Abdel-Razek AS; Department of Chemistry, Faculty of Science, Al-Azhar University, Nasr City-Cairo 11884, Egypt. abdohamed481@yahoo.com.
  • Frese M; Organic and Bioorganic Chemistry, Faculty of Chemistry, Bielefeld University, D-33501 Bielefeld, Germany.
  • Stammler HG; Department of Microbial Chemistry, Division of Genetic Engineering and Biotechnology Research, National Research Centre, El-Buhouth St. 33, Dokki-Cairo 12622, Egypt.
  • El-Haddad AF; Organic and Bioorganic Chemistry, Faculty of Chemistry, Bielefeld University, D-33501 Bielefeld, Germany. marcel.frese@uni-bielefeld.de.
  • Ibrahim TMA; Department of Chemistry, Inorganic and Structural Chemistry, Bielefeld University, D-33501 Bielefeld, Germany. georg.stammler@uni-bielefeld.de.
  • Sewald N; Department of Chemistry, Faculty of Science, Al-Azhar University, Nasr City-Cairo 11884, Egypt. ahmedshukri_sci@yahoo.com.
  • Shaaban M; Department of Chemistry, Faculty of Science, Al-Azhar University, Nasr City-Cairo 11884, Egypt. tarekmostafaahmedibrahim@yahoo.com.
Molecules ; 23(2)2018 Jan 31.
Article em En | MEDLINE | ID: mdl-29385078
ABSTRACT
Terretonin N (1), a new highly oxygenated and unique tetracyclic 6-hydroxymeroterpenoid, was isolated together with seven known compounds from the ethyl acetate extract of a solid-state fermented culture of Nocardiopsis sp. Their structures were elucidated by spectroscopic analysis. The structure and absolute configuration of 1 were unambiguously determined by X-ray crystallography. The isolation and taxonomic characterization of Nocardiopsis sp. is reported. The antimicrobial activity and cytotoxicity of the strain extract and compound 1 were studied using different microorganisms and a cervix carcinoma cell line, respectively.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Actinobacteria / Monoterpenos Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Alemanha
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Actinobacteria / Monoterpenos Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Alemanha