Sedative effects of intramuscular alfaxalone in pet guinea pigs (Cavia porcellus).
Vet Anaesth Analg
; 45(2): 183-189, 2018 Mar.
Article
em En
| MEDLINE
| ID: mdl-29398530
ABSTRACT
OBJECTIVE:
To evaluate the efficacy and side effects of alfaxalone administered intramuscularly (IM) as a sedative agent in guinea pigs undergoing survey radiographs. STUDYDESIGN:
Prospective clinical trial. ANIMALS A total of 30 client-owned guinea pigs.METHODS:
Following baseline assessments, 5 mg kg-1 alfaxalone was administered IM. Heart rate, arterial haemoglobin oxygen saturation, respiratory rate, rectal body temperature, palpebral reflex, response to toe and ear pinch, righting reflex, posture, jaw tone and reaction to manipulation were assessed before and after sedation at 5-minute intervals. The time elapsed from onset of sedation to return of locomotion and coordinated limb movements, the quality of recovery and the occurrence of undesired effects were observed and recorded.RESULTS:
The mean ± standard deviation onset of sedation was 2.7 ± 0.6 minutes. The physiological variables remained within normal ranges until completion of the procedure. Palpebral reflex and responsiveness to both ear and toe pinch were maintained during sedation. Neither hypoxaemia nor hypothermia was observed. The duration of sedation was 29.3 ± 3.2 minutes. Sedation and recovery were uneventful, and adverse effects were not observed. CONCLUSIONS AND CLINICAL RELEVANCE In conclusion, 5 mg kg-1 of IM alfaxalone represents a valuable sedation protocol for healthy guinea pigs undergoing minor noninvasive procedures. Further trials are required to investigate its cardiovascular effects, clinical usefulness in unhealthy patients and its combined use with analgesics for procedures associated with nociception.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pregnanodionas
/
Cobaias
/
Hipnóticos e Sedativos
/
Anestesia
Tipo de estudo:
Guideline
/
Observational_studies
/
Risk_factors_studies
Limite:
Animals
Idioma:
En
Revista:
Vet Anaesth Analg
Assunto da revista:
ANESTESIOLOGIA
/
MEDICINA VETERINARIA
Ano de publicação:
2018
Tipo de documento:
Article