Mutagenicity and genotoxicity studies of aspartame.
Regul Toxicol Pharmacol
; 103: 345-351, 2019 Apr.
Article
em En
| MEDLINE
| ID: mdl-29408486
ABSTRACT
Two studies were conducted to further assess its mutagenic and genotoxic potential. In a bacterial reverse mutation pre-incubation study, Salmonella typhimurium strains TA100, TA1535, TA98, and TA1537 and Escherichia coli WP2 uvrA were treated with aspartame at concentrations of up to 5000 µg/plate with or without metabolic activation and showed no mutagenic potential. Similarly, in vivo micronucleus testing of aspartame following gavage administration (500-2000â¯mg/kg body weight) to CrljCD1(ICR) strain SPF male mice showed no increase in the proportion of micronucleated polychromatic erythrocytes in bone marrow cells collected and evaluated 24 or 48â¯h post administration. Overall, aspartame had no potential for mutagenic or genotoxic activity.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Aspartame
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Edulcorantes
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Mutagênicos
Limite:
Animals
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Humans
Idioma:
En
Revista:
Regul Toxicol Pharmacol
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Japão