Charactering the metabolism of cryptotanshinone by human P450 enzymes and uridine diphosphate glucuronosyltransferases in vitro.

Zeng, Jin; Fan, Yu-Juan; Tan, Bo; Su, Hui-Zong; Li, Yue; Zhang, Lin-Lin; Jiang, Jian; Qiu, Fu-Rong

Zeng, Jin; Fan, Yu-Juan; Tan, Bo; Su, Hui-Zong; Li, Yue; Zhang, Lin-Lin; Jiang, Jian; Qiu, Fu-Rong.

Afiliação

Zeng J; Department of Clinical Pharmacology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Fan YJ; Department of Clinical Pharmacology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Tan B; Department of Clinical Pharmacology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Su HZ; Department of Clinical Pharmacology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Li Y; Department of Clinical Pharmacology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Zhang LL; Department of Clinical Pharmacology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Jiang J; Department of Clinical Pharmacology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. Jiangjiansg@126.com.
Qiu FR; Department of Clinical Pharmacology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. Furong_qiu@126.com.

Acta Pharmacol Sin ; 39(8): 1393-1404, 2018 Aug.

Article em En | MEDLINE | ID: mdl-29417949

Assuntos

Sistema Enzimático do Citocromo P-450/metabolismo; Glucuronosiltransferase/metabolismo; Fenantrenos/metabolismo; Inibidores das Enzimas do Citocromo P-450/farmacologia; Ensaios Enzimáticos; Glucuronídeos/biossíntese; Glucuronídeos/química; Humanos; Microssomos Hepáticos/metabolismo; Estrutura Molecular; NAD(P)H Desidrogenase (Quinona)/metabolismo; Fenantrenos/química; Proteínas Recombinantes/metabolismo

Palavras-chave

P450 enzymes; cryptotanshinone; human liver microsomes; metabolic characteristics; uridine diphosphate glucuronosyltransferases

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fenantrenos / Glucuronosiltransferase / Sistema Enzimático do Citocromo P-450 Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Acta Pharmacol Sin Assunto da revista: FARMACOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China

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