Astrocyte-derived interleukin-33 promotes microglial synapse engulfment and neural circuit development.
Science
; 359(6381): 1269-1273, 2018 03 16.
Article
em En
| MEDLINE
| ID: mdl-29420261
ABSTRACT
Neuronal synapse formation and remodeling are essential to central nervous system (CNS) development and are dysfunctional in neurodevelopmental diseases. Innate immune signals regulate tissue remodeling in the periphery, but how this affects CNS synapses is largely unknown. Here, we show that the interleukin-1 family cytokine interleukin-33 (IL-33) is produced by developing astrocytes and is developmentally required for normal synapse numbers and neural circuit function in the spinal cord and thalamus. We find that IL-33 signals primarily to microglia under physiologic conditions, that it promotes microglial synapse engulfment, and that it can drive microglial-dependent synapse depletion in vivo. These data reveal a cytokine-mediated mechanism required to maintain synapse homeostasis during CNS development.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sinapses
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Sistema Nervoso Central
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Astrócitos
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Microglia
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Neurogênese
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Interleucina-33
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Rede Nervosa
Limite:
Animals
Idioma:
En
Revista:
Science
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Estados Unidos