The Role of Ceramide Synthases in the Pathogenicity of Cryptococcus neoformans.
Cell Rep
; 22(6): 1392-1400, 2018 02 06.
Article
em En
| MEDLINE
| ID: mdl-29425496
ABSTRACT
Cryptococcus neoformans (C. neoformans) is estimated to cause about 220,000 new cases every year in patients with AIDS, despite advances in antifungal treatments. C. neoformans possesses a remarkable ability to disseminate through an immunocompromised host, making treatment difficult. Here, we examine the mechanism of survival of C. neoformans under varying host conditions and find a role for ceramide synthase in C. neoformans virulence. This study also provides a detailed lipidomics resource for the fungal lipid research community in addition to discovering a potential target for antifungal therapy.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Oxirredutases
/
Proteínas Fúngicas
/
Cryptococcus neoformans
/
Fatores de Virulência
Limite:
Animals
Idioma:
En
Revista:
Cell Rep
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Estados Unidos