Multicenter evaluation of guideline adherence for pelvic lymph node dissection in patients undergoing open retropubic vs. laparoscopic or robot assisted radical prostatectomy according to the recent German S3 guideline on prostate cancer.
World J Urol
; 36(6): 855-861, 2018 Jun.
Article
em En
| MEDLINE
| ID: mdl-29427005
ABSTRACT
PURPOSE:
Pelvic lymph node dissection (PLND) is recommended for patients with prostate cancer (PCa) and significant risk for nodal metastases. This study aimed to assess guideline adherence regarding PLND according to the German S3 guideline as example for a national but highly used guideline on prostate cancer and to compare the rate of complications different approaches for radical prostatectomy (RP).METHODS:
Patients undergoing open (RRP), laparoscopic (LARP) or robot-assisted (RARP) RP in six centers in Germany and Austria were included. The primary endpoint was the total number of removed lymph nodes (LN) between the different surgical approaches according to recent guideline recommendations. Secondary endpoints were the number of patients undergoing a sufficient PLND, defined as a removal of at least 10 LN and associated complication rates.RESULTS:
2634 patients undergoing RP were included (RRP 66%, RARP/LARP 34%). PLND was performed in 88% (RRP 88.5%, RARP/LARP 86.8%, p = 0.208). In intermediateor high risk PCa, PLND was performed in 97.2% (RRP 97.7%, RARP/LARP 96.2, p = 0.048). Of those, the mean number of LN was 19 (RRP 19 vs. RARP/LARP 17, p < 0.005) and sufficient PLND was observed in 84.6% of RRP compared to 77.2% of RARP/LARP (p < 0.005). Symptomatic lymphoceles requiring surgical treatment occurred more often in RRP than in RARP/LARP (4.0% vs. 1.6%, p = 0.001).CONCLUSIONS:
The general guideline adherence regarding performing PNLD and the LN yield is high, regardless of the surgical approach. As expected, lymph node yield was higher when very experienced surgeons conducted the procedure. This should be considered in patients' counseling.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Prostatectomia
/
Neoplasias da Próstata
/
Fidelidade a Diretrizes
/
Excisão de Linfonodo
Tipo de estudo:
Evaluation_studies
/
Guideline
/
Observational_studies
/
Risk_factors_studies
Limite:
Humans
/
Male
País/Região como assunto:
Europa
Idioma:
En
Revista:
World J Urol
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Alemanha