Risk factors and metabolic abnormality of patients with non-alcoholic fatty liver disease: Either non-obese or obese Chinese population.
Hepatobiliary Pancreat Dis Int
; 17(1): 45-48, 2018 Feb.
Article
em En
| MEDLINE
| ID: mdl-29428103
ABSTRACT
BACKGROUND:
Non-alcoholic fatty liver disease (NAFLD) occurs not only in obese individuals but also in non-obese ones. The aim of this study was to focus on the association between NAFLD and metabolic events in a non-obese or obese Chinese population.METHODS:
Data collected from subjects registered at Taichung Veterans General Hospital from January to December 2009 were analyzed. The exclusion criteria were alcoholics, chronic hepatitis B or C. Patients included in analyses were assigned to four groups according to sonography of their liver (normal or NAFLD), and body mass index (BMI) levels (non-obese if BMIâ¯<â¯25â¯kg/m2 or obese if BMIâ¯≥â¯25â¯kg/m2).RESULTS:
There were 745, 208, 770 and 285 patients enrolled in four groups labeled non-obese normal liver (group A), non-obese NAFLD (group B), obese normal liver (group C) and obese NAFLD (group D), respectively. The highest ratio of metabolic syndrome existed in the group B (26.9%), followed by group A (11.7%), group D (10.9%) and finally the group C (5.2%). The positive association with NAFLD in non-obese individuals was significant in triglyceride (ORâ¯=â¯1.01; 95% CI 1.01-1.02) and glucose (ORâ¯=â¯1.02; 95% CI 1.01-1.03), while the positive association with NAFLD in obese subjects was only significant in triglyceride (ORâ¯=â¯1.01; 95% CI 1.01-1.02). The positive association was most significant in all cases (adjusted ORâ¯=â¯2.41; 95% CI 1.78-3.24), especially in non-obese individuals (ORâ¯=â¯2.81; 95% CI 1.92-4.12).CONCLUSIONS:
Non-obese NAFLD subjects displayed a higher proportion of metabolic abnormality. Hyperlipidemia and hyperglycemia had the most positive strength association with NAFLD.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Hepatopatia Gordurosa não Alcoólica
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Hiperglicemia
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Hiperlipidemias
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Obesidade
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Prevalence_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
País/Região como assunto:
Asia
Idioma:
En
Revista:
Hepatobiliary Pancreat Dis Int
Assunto da revista:
GASTROENTEROLOGIA
Ano de publicação:
2018
Tipo de documento:
Article