Localized neural control of blood flow in the renal cortex of the anaesthetized baboon.

ABSTRACT

Localized neural control of renal cortical blood flow was observed in five chloralose-anaesthetized baboons. Renal artery blood flow was measured with an electromagnetic flowmeter, while superficial renal cortical blood flow was measured with a laser Doppler flowmeter. Stimulation of all renal nerve bundles isolated produced significant reductions in total renal blood flow, but reduced the superficial renal cortical blood flow only in localized areas. Systemic arterial blood pressure did not vary significantly, which suggests that the changes in renal cortical blood flow were neurally mediated and not the result of autoregulation. The renal cortical blood flow response was delayed 1-4 s with respect to the total renal blood flow response. The localization of flow control is consistent with the neuroanatomy of the kidney, and the delayed renal cortical blood flow response is consistent with the vascular anatomy of the kidney and with previous measurements of red cell transit times through the renal cortex.