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Stress response factors drive regrowth of quiescent cells.
Kuang, Zheng; Ji, Hongkai; Boeke, Jef D.
Afiliação
  • Kuang Z; Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA. zheng.kuang@utsouthwestern.edu.
  • Ji H; Department of Biostatistics, Johns Hopkins University School of Public Health, Baltimore, MD, 21205, USA.
  • Boeke JD; Institute for Systems Genetics, Department of Biochemistry and Molecular Pharmacology, NYU Langone Health, New York City, NY, 10016, USA.
Curr Genet ; 64(4): 807-810, 2018 Aug.
Article em En | MEDLINE | ID: mdl-29455333
Quiescent cells exploit an array of transcription factors to activate stress response machinery and maintain survival under nutrient-limited conditions. Our recent findings reveal that these transcription factors also play an important role in the exit of quiescence and regrowth. By studying Saccharomyces cerevisiae under a continuous, nutrient-limited condition, we found that Msn2 and Msn4 function as master regulators of glycolytic genes in the quiescent-like phase. They control the timing of transition from quiescence to growth by regulating the accumulation rate of acetyl-CoA, a key metabolite that is downstream of glycolysis and drives growth. These findings suggest a model that Msn2/4 not only protect the cells from starvation but also facilitate their regrowth from quiescence. Thus, understanding the functions of stress response transcription factors in metabolic regulation will provide deeper insight into how quiescent cells manage the capacity of regrowth.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Acetilcoenzima A / Saccharomyces cerevisiae / Fatores de Transcrição / Proteínas de Saccharomyces cerevisiae / Proteínas de Ligação a DNA Tipo de estudo: Prognostic_studies Idioma: En Revista: Curr Genet Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Acetilcoenzima A / Saccharomyces cerevisiae / Fatores de Transcrição / Proteínas de Saccharomyces cerevisiae / Proteínas de Ligação a DNA Tipo de estudo: Prognostic_studies Idioma: En Revista: Curr Genet Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos