Anti-inflammatory flavone and chalcone derivatives from the roots of Pongamia pinnata (L.) Pierre.
Phytochemistry
; 149: 56-63, 2018 May.
Article
em En
| MEDLINE
| ID: mdl-29459216
ABSTRACT
A phytochemical study on the roots of Pongamia pinnata (L.) Pierre yielded 52 flavonoids, including four previously undescribed flavone and four previously undescribed chalcone derivatives. The structures of the isolated compounds were determined on the basis of the 1D, 2D NMR, and mass spectroscopic data. The absolute configurations of the compounds were assigned via the specific rotation, Mosher's method, as well as the electronic circular dichroism (ECD) spectra. All the isolates were evaluated for their inhibitory effects on NO production in LPS-stimulated BV-2 microglial cells. Ten compounds showed significant inhibitory effects against NO production, comparable to the positive control, dexamethasone.
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Base de dados:
MEDLINE
Assunto principal:
Medicamentos de Ervas Chinesas
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Raízes de Plantas
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Millettia
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Chalconas
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Flavonas
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Anti-Inflamatórios
Limite:
Animals
Idioma:
En
Revista:
Phytochemistry
Ano de publicação:
2018
Tipo de documento:
Article