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Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity.
Janas, Maja M; Schlegel, Mark K; Harbison, Carole E; Yilmaz, Vedat O; Jiang, Yongfeng; Parmar, Rubina; Zlatev, Ivan; Castoreno, Adam; Xu, Huilei; Shulga-Morskaya, Svetlana; Rajeev, Kallanthottathil G; Manoharan, Muthiah; Keirstead, Natalie D; Maier, Martin A; Jadhav, Vasant.
Afiliação
  • Janas MM; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA.
  • Schlegel MK; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA.
  • Harbison CE; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA.
  • Yilmaz VO; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA.
  • Jiang Y; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA.
  • Parmar R; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA.
  • Zlatev I; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA.
  • Castoreno A; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA.
  • Xu H; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA.
  • Shulga-Morskaya S; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA.
  • Rajeev KG; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA.
  • Manoharan M; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA.
  • Keirstead ND; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA.
  • Maier MA; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA.
  • Jadhav V; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA, 02142, USA. vjadhav@alnylam.com.
Nat Commun ; 9(1): 723, 2018 02 19.
Article em En | MEDLINE | ID: mdl-29459660
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Acetilgalactosamina / RNA Interferente Pequeno / Fígado Limite: Animals Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Acetilgalactosamina / RNA Interferente Pequeno / Fígado Limite: Animals Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos