TGF-ß1/TßRII/Smad3 signaling pathway promotes VEGF expression in oral squamous cell carcinoma tumor-associated macrophages.

Sun, Haibin; Miao, Cheng; Liu, Wei; Qiao, Xianghe; Yang, Wenbin; Li, Longjiang; Li, Chunjie

Sun, Haibin; Miao, Cheng; Liu, Wei; Qiao, Xianghe; Yang, Wenbin; Li, Longjiang; Li, Chunjie.

Afiliação

Sun H; Department of Head and Neck Oncology, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan Province 610041, China.
Miao C; Department of Head and Neck Oncology, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan Province 610041, China.
Liu W; Department of Head and Neck Oncology, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan Province 610041, China.
Qiao X; Department of Head and Neck Oncology, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan Province 610041, China.
Yang W; Department of Head and Neck Oncology, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan Province 610041, China.
Li L; Department of Head and Neck Oncology, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan Province 610041, China. Electronic address: lichunjie@scu.edu.cn.
Li C; Department of Head and Neck Oncology, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan Province 610041, China. Electronic address: lichunjie07@qq.com.

Biochem Biophys Res Commun ; 497(2): 583-590, 2018 03 04.

Article em En | MEDLINE | ID: mdl-29462614

Assuntos

Carcinoma de Células Escamosas/patologia; Macrófagos/patologia; Neoplasias Bucais/patologia; Transdução de Sinais; Fator A de Crescimento do Endotélio Vascular/metabolismo; Animais; Carcinoma de Células Escamosas/diagnóstico; Carcinoma de Células Escamosas/metabolismo; Humanos; Macrófagos/metabolismo; Masculino; Camundongos Endogâmicos C57BL; Neoplasias Bucais/diagnóstico; Neoplasias Bucais/metabolismo; Neovascularização Patológica/metabolismo; Neovascularização Patológica/patologia; Prognóstico; Proteínas Serina-Treonina Quinases/análise; Proteínas Serina-Treonina Quinases/metabolismo; Receptor do Fator de Crescimento Transformador beta Tipo II; Receptores de Fatores de Crescimento Transformadores beta/análise; Receptores de Fatores de Crescimento Transformadores beta/metabolismo; Proteína Smad3/análise; Proteína Smad3/metabolismo; Fator de Crescimento Transformador beta1/análise; Fator de Crescimento Transformador beta1/metabolismo; Fator A de Crescimento do Endotélio Vascular/análise

Palavras-chave

Angiogenesis; Macrophages; Oral squamous cell carcinoma; Prognosis; VEGF

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Bucais / Carcinoma de Células Escamosas / Transdução de Sinais / Fator A de Crescimento do Endotélio Vascular / Macrófagos Tipo de estudo: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limite: Animals / Humans / Male Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google