Distinct functions for the membrane-proximal ectodomain region (MPER) of HIV-1 gp41 in cell-free and cell-cell viral transmission and cell-cell fusion.

Narasimhulu, Vani G S; Bellamy-McIntyre, Anna K; Laumaea, Annamarie E; Lay, Chan-Sien; Harrison, David N; King, Hannah A D; Drummer, Heidi E; Poumbourios, Pantelis

Narasimhulu, Vani G S; Bellamy-McIntyre, Anna K; Laumaea, Annamarie E; Lay, Chan-Sien; Harrison, David N; King, Hannah A D; Drummer, Heidi E; Poumbourios, Pantelis.

Afiliação

Narasimhulu VGS; From the Virus Entry and Vaccines Laboratory, Burnet Institute, Melbourne, Victoria 3004.
Bellamy-McIntyre AK; the Department of Microbiology and Immunology at the Peter Doherty Institute, University of Melbourne, Parkville, Victoria 3010, and.
Laumaea AE; From the Virus Entry and Vaccines Laboratory, Burnet Institute, Melbourne, Victoria 3004.
Lay CS; the Departments of Microbiology and.
Harrison DN; From the Virus Entry and Vaccines Laboratory, Burnet Institute, Melbourne, Victoria 3004.
King HAD; the Department of Microbiology and Immunology at the Peter Doherty Institute, University of Melbourne, Parkville, Victoria 3010, and.
Drummer HE; Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia.
Poumbourios P; From the Virus Entry and Vaccines Laboratory, Burnet Institute, Melbourne, Victoria 3004.

J Biol Chem ; 293(16): 6099-6120, 2018 04 20.

Article em En | MEDLINE | ID: mdl-29496992

Assuntos

Proteína gp41 do Envelope de HIV/metabolismo; Infecções por HIV/metabolismo; HIV-1/fisiologia; Fusão de Membrana; Internalização do Vírus; Linhagem Celular; Proteína gp41 do Envelope de HIV/química; Proteína gp41 do Envelope de HIV/genética; Infecções por HIV/transmissão; Infecções por HIV/virologia; HIV-1/genética; Humanos; Modelos Moleculares; Mutação Puntual; Domínios Proteicos; Replicação Viral

Palavras-chave

cellcell transmission; glycoprotein; human immunodeficiency virus (HIV); membrane fusion; mutant; neutralization; viral replication; virus entry

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteína gp41 do Envelope de HIV / Infecções por HIV / HIV-1 / Internalização do Vírus / Fusão de Membrana Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2018 Tipo de documento: Article

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