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A sensitive LC-MS/MS method for simultaneous determination of cabozantinib and its metabolite cabozantinib N-oxide in rat plasma and its application in a pharmacokinetic study.
Ren, Lian-Jie; Wu, Hua-Jing; Sun, Li-Han; Xu, Xue; Mo, Li-Ying; Zhang, Lei; Zhang, Jun-Ying; Wu, Chun-Yong.
Afiliação
  • Ren LJ; Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing, China.
  • Wu HJ; Center for Drug Evaluation, China Food and Drug Administration, Beijing, China.
  • Sun LH; Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing, China.
  • Xu X; Center for Drug Safety Evaluation and Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
  • Mo LY; Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing, China.
  • Zhang L; Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing, China.
  • Zhang JY; Department of Pharmaceutics of Traditional Chinese Medicine, China Pharmaceutical University, Nanjing, China.
  • Wu CY; Department of Chemical Drug Division, Shandong Institute for Food and Drug Control, Shandong, China.
Biomed Chromatogr ; 32(7): e4227, 2018 Jul.
Article em En | MEDLINE | ID: mdl-29500905
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piridinas / Cromatografia Líquida / Espectrometria de Massas em Tandem / Anilidas Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals Idioma: En Revista: Biomed Chromatogr Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piridinas / Cromatografia Líquida / Espectrometria de Massas em Tandem / Anilidas Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals Idioma: En Revista: Biomed Chromatogr Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China