Administration of monthly pulses of cyclophosphamide in multiple sclerosis patients. Delayed recovery of several immune parameters following discontinuation of long-term cyclophosphamide treatment.
J Neuroimmunol
; 14(2): 175-82, 1987 Mar.
Article
em En
| MEDLINE
| ID: mdl-2950131
ABSTRACT
Recovery of various components of the immune system was followed in eight patients with multiple sclerosis who had received monthly pulses of cyclophosphamide (CY) for approximately one year. CD8 cell numbers and NK and ADCC functions recovered in 1-2 months; B cells and FcR+ cell numbers recovered in 2-4 months. The recovery of CD4 cells and total T cell numbers, CD4/CD8 ratio and proliferative responses to PHA took more than 4 months. The impaired proliferation was not attributable to low IL-2 receptor expression. Once immunosuppression has been achieved pulse administration of CY at 2- to 4-month intervals may be feasible for long-term maintenance treatment.
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Base de dados:
MEDLINE
Assunto principal:
Ciclofosfamida
/
Esclerose Múltipla
Limite:
Humans
Idioma:
En
Revista:
J Neuroimmunol
Ano de publicação:
1987
Tipo de documento:
Article