Potent ACE inhibitors from 5-hydroxy indanone derivatives.

Vulupala, Hanmanth Reddy; Sajja, Yasodakrishna; Bagul, Pankaj K; Bandla, Raviteja; Nagarapu, Lingaiah; Benerjee, Sanjay K

Vulupala, Hanmanth Reddy; Sajja, Yasodakrishna; Bagul, Pankaj K; Bandla, Raviteja; Nagarapu, Lingaiah; Benerjee, Sanjay K.

Afiliação

Vulupala HR; Organic Chemistry Division II (CPC), CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500007, India, IICT/Pubs./2018/073.
Sajja Y; Organic Chemistry Division II (CPC), CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500007, India, IICT/Pubs./2018/073.
Bagul PK; Centre for Chemical Biology, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500007, India; Drug Discovery Research Center, Translational Health Science and Technology Institute, Faridabad 121001, India.
Bandla R; Organic Chemistry Division II (CPC), CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500007, India, IICT/Pubs./2018/073.
Nagarapu L; Organic Chemistry Division II (CPC), CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500007, India, IICT/Pubs./2018/073. Electronic address: nagarapu@iict.res.in.
Benerjee SK; Centre for Chemical Biology, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500007, India; Drug Discovery Research Center, Translational Health Science and Technology Institute, Faridabad 121001, India.

Bioorg Chem ; 77: 660-665, 2018 04.

Article em En | MEDLINE | ID: mdl-29502027

Assuntos

Inibidores da Enzima Conversora de Angiotensina/farmacologia; Indanos/farmacologia; Peptidil Dipeptidase A/metabolismo; Inibidores da Enzima Conversora de Angiotensina/síntese química; Inibidores da Enzima Conversora de Angiotensina/química; Relação Dose-Resposta a Droga; Humanos; Indanos/síntese química; Indanos/química; Estrutura Molecular; Relação Estrutura-Atividade

Palavras-chave

ACE inhibitors; Click chemistry; Epi-chlorohydrin; Hypertension; Piperazines; Triazoles; ß-Amino alcohols

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores da Enzima Conversora de Angiotensina / Peptidil Dipeptidase A / Indanos Limite: Humans Idioma: En Revista: Bioorg Chem Ano de publicação: 2018 Tipo de documento: Article

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