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A Phase 1, open-label, multicentre study to compare the capsule and tablet formulations of AZD5363 and explore the effect of food on the pharmacokinetic exposure, safety and tolerability of AZD5363 in patients with advanced solid malignancies: OAK.
Dean, Emma; Banerji, Udai; Schellens, Jan H M; Krebs, Matthew G; Jimenez, Begona; van Brummelen, Emilie; Bailey, Chris; Casson, Ed; Cripps, Diana; Cullberg, Marie; Evans, Stephen; Foxley, Andrew; Lindemann, Justin; Rugman, Paul; Taylor, Nigel; Turner, Guy; Yates, James; Lawrence, Peter.
Afiliação
  • Dean E; The Christie NHS Foundation Trust, The University of Manchester, Manchester, UK. emma.dean@astrazeneca.com.
  • Banerji U; AstraZeneca, Da Vinci Building, Melbourn Science Park, Melbourn, Hertfordshire, SG8 6HB, UK. emma.dean@astrazeneca.com.
  • Schellens JHM; Royal Marsden Hospital, London, UK.
  • Krebs MG; Netherlands Cancer Institute, Amsterdam, The Netherlands.
  • Jimenez B; The Christie NHS Foundation Trust, The University of Manchester, Manchester, UK.
  • van Brummelen E; Royal Marsden Hospital, London, UK.
  • Bailey C; Netherlands Cancer Institute, Amsterdam, The Netherlands.
  • Casson E; IMED Biotech Unit, AstraZeneca, Cambridge, UK.
  • Cripps D; IMED Biotech Unit, AstraZeneca, Cambridge, UK.
  • Cullberg M; IMED Biotech Unit, AstraZeneca, Cambridge, UK.
  • Evans S; IMED Biotech Unit, AstraZeneca, Cambridge, UK.
  • Foxley A; AstraZeneca, Macclesfield, UK.
  • Lindemann J; IMED Biotech Unit, AstraZeneca, Cambridge, UK.
  • Rugman P; IMED Biotech Unit, AstraZeneca, Cambridge, UK.
  • Taylor N; IMED Biotech Unit, AstraZeneca, Cambridge, UK.
  • Turner G; AstraZeneca, Macclesfield, UK.
  • Yates J; AstraZeneca, Macclesfield, UK.
  • Lawrence P; IMED Biotech Unit, AstraZeneca, Cambridge, UK.
Cancer Chemother Pharmacol ; 81(5): 873-883, 2018 05.
Article em En | MEDLINE | ID: mdl-29541803
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirimidinas / Pirróis / Interações Alimento-Droga / Neoplasias / Antineoplásicos Tipo de estudo: Clinical_trials Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Cancer Chemother Pharmacol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirimidinas / Pirróis / Interações Alimento-Droga / Neoplasias / Antineoplásicos Tipo de estudo: Clinical_trials Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Cancer Chemother Pharmacol Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Reino Unido