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Discovery and Optimization of Phosphopantetheine Adenylyltransferase Inhibitors with Gram-Negative Antibacterial Activity.
Skepper, Colin K; Moreau, Robert J; Appleton, Brent A; Benton, Bret M; Drumm, Joseph E; Feng, Brian Y; Geng, Mei; Hu, Cheng; Li, Cindy; Lingel, Andreas; Lu, Yipin; Mamo, Mulugeta; Mergo, Wosenu; Mostafavi, Mina; Rath, Christopher M; Steffek, Micah; Takeoka, Kenneth T; Uehara, Kyoko; Wang, Lisha; Wei, Jun-Rong; Xie, Lili; Xu, Wenjian; Zhang, Qiong; de Vicente, Javier.
Afiliação
  • Skepper CK; Novartis Institutes for Biomedical Research, 5300 Chiron Way , Emeryville , California 94608 , United States.
  • Moreau RJ; Novartis Institutes for Biomedical Research, 5300 Chiron Way , Emeryville , California 94608 , United States.
  • Appleton BA; Novartis Institutes for Biomedical Research, 5300 Chiron Way , Emeryville , California 94608 , United States.
  • Benton BM; Novartis Institutes for Biomedical Research, 5300 Chiron Way , Emeryville , California 94608 , United States.
  • Drumm JE; Novartis Institutes for Biomedical Research, 5300 Chiron Way , Emeryville , California 94608 , United States.
  • Feng BY; Novartis Institutes for Biomedical Research, 5300 Chiron Way , Emeryville , California 94608 , United States.
  • Geng M; Novartis Institutes for Biomedical Research, 5300 Chiron Way , Emeryville , California 94608 , United States.
  • Hu C; Novartis Institutes for Biomedical Research, 5300 Chiron Way , Emeryville , California 94608 , United States.
  • Li C; Novartis Institutes for Biomedical Research, 5300 Chiron Way , Emeryville , California 94608 , United States.
  • Lingel A; Novartis Institutes for Biomedical Research, 5300 Chiron Way , Emeryville , California 94608 , United States.
  • Lu Y; Novartis Institutes for Biomedical Research, 5300 Chiron Way , Emeryville , California 94608 , United States.
  • Mamo M; Novartis Institutes for Biomedical Research, 5300 Chiron Way , Emeryville , California 94608 , United States.
  • Mergo W; Novartis Institutes for Biomedical Research, 5300 Chiron Way , Emeryville , California 94608 , United States.
  • Mostafavi M; Novartis Institutes for Biomedical Research, 5300 Chiron Way , Emeryville , California 94608 , United States.
  • Rath CM; Novartis Institutes for Biomedical Research, 5300 Chiron Way , Emeryville , California 94608 , United States.
  • Steffek M; Novartis Institutes for Biomedical Research, 5300 Chiron Way , Emeryville , California 94608 , United States.
  • Takeoka KT; Novartis Institutes for Biomedical Research, 5300 Chiron Way , Emeryville , California 94608 , United States.
  • Uehara K; Novartis Institutes for Biomedical Research, 5300 Chiron Way , Emeryville , California 94608 , United States.
  • Wang L; Novartis Institutes for Biomedical Research, 5300 Chiron Way , Emeryville , California 94608 , United States.
  • Wei JR; Novartis Institutes for Biomedical Research, 5300 Chiron Way , Emeryville , California 94608 , United States.
  • Xie L; Novartis Institutes for Biomedical Research, 5300 Chiron Way , Emeryville , California 94608 , United States.
  • Xu W; Novartis Institutes for Biomedical Research, 5300 Chiron Way , Emeryville , California 94608 , United States.
  • Zhang Q; Novartis Institutes for Biomedical Research, 5300 Chiron Way , Emeryville , California 94608 , United States.
  • de Vicente J; Novartis Institutes for Biomedical Research, 5300 Chiron Way , Emeryville , California 94608 , United States.
J Med Chem ; 61(8): 3325-3349, 2018 04 26.
Article em En | MEDLINE | ID: mdl-29551072
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Escherichia coli / Inibidores Enzimáticos / Compostos Heterocíclicos com 2 Anéis / Antibacterianos / Nucleotidiltransferases Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Escherichia coli / Inibidores Enzimáticos / Compostos Heterocíclicos com 2 Anéis / Antibacterianos / Nucleotidiltransferases Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos